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Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.
Lotta, Luca A; Gulati, Pawan; Day, Felix R; Payne, Felicity; Ongen, Halit; van de Bunt, Martijn; Gaulton, Kyle J; Eicher, John D; Sharp, Stephen J; Luan, Jian'an; De Lucia Rolfe, Emanuella; Stewart, Isobel D; Wheeler, Eleanor; Willems, Sara M; Adams, Claire; Yaghootkar, Hanieh; Forouhi, Nita G; Khaw, Kay-Tee; Johnson, Andrew D; Semple, Robert K; Frayling, Timothy; Perry, John R B; Dermitzakis, Emmanouil; McCarthy, Mark I; Barroso, Inês; Wareham, Nicholas J; Savage, David B; Langenberg, Claudia; O'Rahilly, Stephen; Scott, Robert A.
Afiliación
  • Lotta LA; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Gulati P; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Day FR; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Payne F; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Ongen H; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
  • van de Bunt M; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Gaulton KJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Eicher JD; Department of Pediatrics, University of California at San Diego, La Jolla, California, USA.
  • Sharp SJ; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
  • Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • De Lucia Rolfe E; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Stewart ID; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Wheeler E; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Willems SM; Wellcome Trust Sanger Institute, Hinxton, UK.
  • Adams C; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Yaghootkar H; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Khaw KT; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Johnson AD; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Semple RK; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
  • Frayling T; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Perry JR; Genetics of Complex Traits, Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.
  • Dermitzakis E; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • McCarthy MI; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
  • Barroso I; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
  • Wareham NJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Savage DB; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
  • Langenberg C; Wellcome Trust Sanger Institute, Hinxton, UK.
  • O'Rahilly S; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
  • Scott RA; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Nat Genet ; 49(1): 17-26, 2017 01.
Article en En | MEDLINE | ID: mdl-27841877
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Enfermedades Cardiovasculares / Tejido Adiposo / Genómica / Enfermedades Metabólicas / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Enfermedades Cardiovasculares / Tejido Adiposo / Genómica / Enfermedades Metabólicas / Obesidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos