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Cardioprotection and lifespan extension by the natural polyamine spermidine.
Eisenberg, Tobias; Abdellatif, Mahmoud; Schroeder, Sabrina; Primessnig, Uwe; Stekovic, Slaven; Pendl, Tobias; Harger, Alexandra; Schipke, Julia; Zimmermann, Andreas; Schmidt, Albrecht; Tong, Mingming; Ruckenstuhl, Christoph; Dammbrueck, Christopher; Gross, Angelina S; Herbst, Viktoria; Magnes, Christoph; Trausinger, Gert; Narath, Sophie; Meinitzer, Andreas; Hu, Zehan; Kirsch, Alexander; Eller, Kathrin; Carmona-Gutierrez, Didac; Büttner, Sabrina; Pietrocola, Federico; Knittelfelder, Oskar; Schrepfer, Emilie; Rockenfeller, Patrick; Simonini, Corinna; Rahn, Alexandros; Horsch, Marion; Moreth, Kristin; Beckers, Johannes; Fuchs, Helmut; Gailus-Durner, Valerie; Neff, Frauke; Janik, Dirk; Rathkolb, Birgit; Rozman, Jan; de Angelis, Martin Hrabe; Moustafa, Tarek; Haemmerle, Guenter; Mayr, Manuel; Willeit, Peter; von Frieling-Salewsky, Marion; Pieske, Burkert; Scorrano, Luca; Pieber, Thomas; Pechlaner, Raimund; Willeit, Johann.
Afiliación
  • Eisenberg T; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Abdellatif M; BioTechMed Graz, Graz, Austria.
  • Schroeder S; Department of Cardiology, Medical University of Graz, Graz, Austria.
  • Primessnig U; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Stekovic S; Department of Cardiology, Medical University of Graz, Graz, Austria.
  • Pendl T; Department of Internal Medicine and Cardiology, Campus Virchow-Klinikum, Charité-University Medicine Berlin, Berlin, Germany.
  • Harger A; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Schipke J; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Zimmermann A; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Schmidt A; Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  • Tong M; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
  • Ruckenstuhl C; Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy), Hannover, Germany.
  • Dammbrueck C; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Gross AS; Department of Cardiology, Medical University of Graz, Graz, Austria.
  • Herbst V; Department of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark, USA.
  • Magnes C; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Trausinger G; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Narath S; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Meinitzer A; Department of Cardiology, Medical University of Graz, Graz, Austria.
  • Hu Z; Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria.
  • Kirsch A; Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria.
  • Eller K; Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria.
  • Carmona-Gutierrez D; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.
  • Büttner S; FRIAS Freiburg Institute for Advanced Studies, Department of Dermatology, Medical Center, ZBSA Center for Biological Systems Analysis, BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
  • Pietrocola F; Department of Biology, University of Fribourg, Fribourg, Switzerland.
  • Knittelfelder O; Clinical division of Nephrology, Medical University of Graz, Graz, Austria.
  • Schrepfer E; Clinical division of Nephrology, Medical University of Graz, Graz, Austria.
  • Rockenfeller P; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Simonini C; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Rahn A; Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  • Horsch M; Equipe 11 Labellisée Ligue Contre le Cancer, Centre de Recherche des Cordeliers, Paris, France.
  • Moreth K; Cell Biology and Metabolomics Platforms, Gustave Roussy Comprehensive Cancer Center, Villejuif, France.
  • Beckers J; INSERM, U1138, Paris, France.
  • Fuchs H; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
  • Gailus-Durner V; Université Pierre et Marie Curie, Paris, France.
  • Neff F; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • Janik D; Department of Biology, University of Padua, Padua, Italy.
  • Rathkolb B; Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padua, Italy.
  • Rozman J; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
  • de Angelis MH; Kent Fungal Group, School of Biosciences, University of Kent, Canterbury, UK.
  • Moustafa T; Department of Cardiology, Medical University of Graz, Graz, Austria.
  • Haemmerle G; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
  • Mayr M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Willeit P; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • von Frieling-Salewsky M; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Pieske B; Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Freising, Germany.
  • Scorrano L; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Pieber T; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Pechlaner R; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Willeit J; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Nat Med ; 22(12): 1428-1438, 2016 12.
Article en En | MEDLINE | ID: mdl-27841876
Aging is associated with an increased risk of cardiovascular disease and death. Here we show that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Spermidine feeding enhanced cardiac autophagy, mitophagy and mitochondrial respiration, and it also improved the mechano-elastical properties of cardiomyocytes in vivo, coinciding with increased titin phosphorylation and suppressed subclinical inflammation. Spermidine feeding failed to provide cardioprotection in mice that lack the autophagy-related protein Atg5 in cardiomyocytes. In Dahl salt-sensitive rats that were fed a high-salt diet, a model for hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, increased titin phosphorylation and prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. In humans, high levels of dietary spermidine, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease. Our results suggest a new and feasible strategy for protection against cardiovascular disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Presión Sanguínea / Envejecimiento / Espermidina / Miocitos Cardíacos / Mitofagia / Corazón / Longevidad / Mitocondrias Cardíacas Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autofagia / Presión Sanguínea / Envejecimiento / Espermidina / Miocitos Cardíacos / Mitofagia / Corazón / Longevidad / Mitocondrias Cardíacas Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2016 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos