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Evaluation of DNA/Protein interactions and cytotoxic studies of copper(II) complexes incorporated with N, N donor ligands and terpyridine ligand.
Tummalapalli, Kiran; C S, Vasavi; Munusami, Punnagai; Pathak, Madhvesh; M M, Balamurali.
Afiliación
  • Tummalapalli K; Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, Tamilnadu 632014, India.
  • C S V; Bioinformatics Division, School of Bio Sciences and Technology, VIT University, Vellore, Tamil Nadu 632 014, India.
  • Munusami P; Center for Computational Natural Sciences and Bioinformatics, International Institute of Information Technology, Hyderabad 500 032, India.
  • Pathak M; Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, Tamilnadu 632014, India. Electronic address: madhveshpathak@vit.ac.
  • M M B; Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, Tamilnadu 632014, India. Electronic address: balamurali.mm@vit.ac.in.
Int J Biol Macromol ; 95: 1254-1266, 2017 Feb.
Article en En | MEDLINE | ID: mdl-27838416
A series of four new copper(II) heteroleptic complexes, [Cu(2‴-pytpy) (L)] (NO3)2·2H2O (1-4), where 2‴-pytpy=4'-(2'''-Pyridyl)-2, 2':6', 2''-terpyridine, L=bipyridyl (bpy), 1, 10 phenanthroline(phen), dipyridoquinoxaline(dpq) and dipyridophenazine (dppz) were synthesized and characterized by spectroscopic techniques. Further, the molecular structure of the complex (2) was confirmed by single crystal X-ray diffraction technique and the data revealed a penta coordinated, distorted square-pyramidal geometry with triclinic system. The interactions of four complexes with calf thymus DNA and bovine serum albumin (BSA) were investigated by electronic absorption, fluorescence and circular dichroism spectroscopy techniques. Spectral studies substantiated an intercalative binding mode of metal complexes with ct-DNA. Significant binding interactions of the complexes with protein have been further revealed from fluorescence studies. Furthermore, all the four complexes show potential cytotoxicity towards the human liver carcinoma cell line (HepG-2).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Quinoxalinas / Albúmina Sérica Bovina / Complejos de Coordinación / Sustancias Intercalantes / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organometálicos / Quinoxalinas / Albúmina Sérica Bovina / Complejos de Coordinación / Sustancias Intercalantes / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Int J Biol Macromol Año: 2017 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos