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Graft versus self (GvS) against T-cell autoantigens is a mechanism of graft-host interaction.
Mirza, Nora; Zierhut, Manfred; Korn, Andreas; Bornemann, Antje; Vogel, Wichard; Schmid-Horch, Barbara; Bethge, Wolfgang A; Stevanovic, Stefan; Salih, Helmut R; Kanz, Lothar; Rammensee, Hans-Georg; Haen, Sebastian P.
Afiliación
  • Mirza N; Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, D-72076 Tuebingen, Germany.
  • Zierhut M; Abteilung Immunologie, Interfakultaeres Institut fuer Zellbiologie, D-72076 Tuebingen, Germany.
  • Korn A; Universitaetsaugenklinik, D-72076 Tuebingen, Germany.
  • Bornemann A; Klinik fuer diagnostische und interventionelle Neuroradiologie, D-72076 Tuebingen, Germany.
  • Vogel W; Institut fuer Neuropathologie, D-72076 Tuebingen, Germany.
  • Schmid-Horch B; Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, D-72076 Tuebingen, Germany.
  • Bethge WA; Zentrum fuer klinische Transfusionsmedizin, D-72076 Tuebingen, Germany.
  • Stevanovic S; Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, D-72076 Tuebingen, Germany.
  • Salih HR; Abteilung Immunologie, Interfakultaeres Institut fuer Zellbiologie, D-72076 Tuebingen, Germany.
  • Kanz L; Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, D-72076 Tuebingen, Germany.
  • Rammensee HG; Department for Internal Medicine II, Clinical Collaboration Unit Translational Immunology, German Cancer Consortium and German Cancer Research Center, Partner site Tuebingen, D-72076 Tuebingen, Germany.
  • Haen SP; Abteilung II fuer Onkologie, Haematologie, Immunologie, Rheumatologie, und Pulmologie, Medizinische Universitaetsklinik, D-72076 Tuebingen, Germany.
Proc Natl Acad Sci U S A ; 113(48): 13827-13832, 2016 11 29.
Article en En | MEDLINE | ID: mdl-27834728
Graft-versus-host disease (GVHD) represents the major nonrelapse complication of allogeneic hematopoietic cell transplantation. Although rare, the CNS and the eye can be affected. In this study, manifestation in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells were evaluated. In 2 of 6 patients with posttransplantation retina diseases and 6 of 22 patients without ocular symptoms, antigen-specific T-cell responses against retina-specific epitopes were observed. No genetic differences between donor and recipient could be identified indicating T-cell activation against self-antigens (graft versus self). Transplantation of a preexisting immunity and cross-reactivity with ubiquitous epitopes was excluded in family donors and healthy individuals. In summary, an immunological reaction against retina cells represents a mechanism of graft-versus-host interaction following hematopoietic cell transplantation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Retina / Autoantígenos / Epítopos de Linfocito T / Enfermedad Injerto contra Huésped Tipo de estudio: Etiology_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Retina / Autoantígenos / Epítopos de Linfocito T / Enfermedad Injerto contra Huésped Tipo de estudio: Etiology_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos