Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1ß Production.

Ceneri, Nicolle; Zhao, Lina; Young, Bryan D; Healy, Abigail; Coskun, Suleyman; Vasavada, Hema; Yarovinsky, Timur O; Ike, Kenneth; Pardi, Ruggero; Qin, Lingfen; Qin, Li; Tellides, George; Hirschi, Karen; Meadows, Judith; Soufer, Robert; Chun, Hyung J; Sadeghi, Mehran M; Bender, Jeffrey R; Morrison, Alan R

Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1ß Production.

Ceneri, Nicolle; Zhao, Lina; Young, Bryan D; Healy, Abigail; Coskun, Suleyman; Vasavada, Hema; Yarovinsky, Timur O; Ike, Kenneth; Pardi, Ruggero; Qin, Lingfen; Qin, Li; Tellides, George; Hirschi, Karen; Meadows, Judith; Soufer, Robert; Chun, Hyung J; Sadeghi, Mehran M; Bender, Jeffrey R; Morrison, Alan R.

Afiliación

Ceneri N; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Zhao L; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Young BD; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Healy A; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Coskun S; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Vasavada H; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Yarovinsky TO; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Ike K; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Pardi R; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Qin L; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Qin L; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Tellides G; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Hirschi K; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Meadows J; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Soufer R; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Chun HJ; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Sadeghi MM; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Bender JR; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In
Morrison AR; From the Department of Internal Medicine (Section of Cardiovascular Medicine), VA Connecticut Healthcare System, West Haven (N.C., L.Z., A.H., L.Q., G.T., J.M., R.S., M.M.S., A.R.M.); Department of Medicine and Division of Cardiology, Providence VA Medical Center, RI (A.H., A.R.M.); Department of In

Arterioscler Thromb Vasc Biol ; 37(2): 328-340, 2017 Feb.

Article en En | MEDLINE | ID: mdl-27834690

Asunto(s)

Enfermedades de la Aorta/enzimología; Aterosclerosis/enzimología; Enfermedad de la Arteria Coronaria/enzimología; Mediadores de Inflamación/metabolismo; Interleucina-1beta/metabolismo; Macrófagos/enzimología; Placa Aterosclerótica; Calcificación Vascular/enzimología; Proteínas de Unión al GTP rac/metabolismo; Animales; Aorta/enzimología; Aorta/patología; Enfermedades de la Aorta/genética; Enfermedades de la Aorta/patología; Enfermedades de la Aorta/prevención & control; Apolipoproteínas E/deficiencia; Apolipoproteínas E/genética; Aterosclerosis/genética; Aterosclerosis/patología; Aterosclerosis/prevención & control; Células Cultivadas; Enfermedad de la Arteria Coronaria/mortalidad; Enfermedad de la Arteria Coronaria/patología; Vasos Coronarios/enzimología; Vasos Coronarios/patología; Femenino; Predisposición Genética a la Enfermedad; Humanos; Proteína Antagonista del Receptor de Interleucina 1/farmacología; Macrófagos/patología; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Músculo Liso Vascular/enzimología; Músculo Liso Vascular/patología; Miocitos del Músculo Liso/enzimología; Miocitos del Músculo Liso/patología; Neuropéptidos/metabolismo; Fenotipo; Pronóstico; Transducción de Señal; Transfección; Regulación hacia Arriba; Calcificación Vascular/mortalidad; Calcificación Vascular/patología; Proteínas de Unión al GTP rac/deficiencia; Proteínas de Unión al GTP rac/genética; Proteína de Unión al GTP rac1/metabolismo; Proteína RCA2 de Unión a GTP

Palabras clave

atherosclerosis; biomarkers; coronary artery disease; inflammation; macrophages

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Aorta / Enfermedad de la Arteria Coronaria / Mediadores de Inflamación / Proteínas de Unión al GTP rac / Aterosclerosis / Interleucina-1beta / Placa Aterosclerótica / Calcificación Vascular / Macrófagos Tipo de estudio: Prognostic_studies Idioma: En Revista: Arterioscler Thromb Vasc Biol Asunto de la revista: ANGIOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google