Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice.
Mol Metab
; 5(11): 1072-1082, 2016 11.
Article
en En
| MEDLINE
| ID: mdl-27818933
Palabras clave
2-DG, 2-Deoxy-d-glucose; Citrate transport; EE, energy expenditure; EGP, endogenous glucose production; FA, fatty acids; FLD, fatty liver disease; GIR, glucose infusion rate; HE clamp, hyperinsulinemic-euglycemic clamp; HFD, high-fat diet; IEX, anion-exchange high-performance liquid chromatography; INDY, 'I'm not dead Yet'; INDY/Slc13a5; Insulin resistance; KO, knockout; Lipid accumulation; ORO, oil red O; RER, respiratory exchange ratio; SCR, non-silencing scrambled control siRNA; SKM, skeletal muscle; Steatosis; T2D, type-2 diabetes; TCA, tricarboxylic acid; WAT, white adipose tissue; WD, western diet; e, epididymal; mINDY, Slc13a5/SLC13A5; p, perirenal; s, subcutaneous; siINDY, mINDY-specific siRNA; siRNA; solute carrier family 13, member 5
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
/
Transportadores de Ácidos Dicarboxílicos
/
Simportadores
/
Interferencia de ARN
/
Metabolismo de los Lípidos
/
Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Mol Metab
Año:
2016
Tipo del documento:
Article
Pais de publicación:
Alemania