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Towards a New Paradigm in Nano-Genotoxicology: Facing Complexity of Nanomaterials' Cellular Interactions and Effects.
Gonzalez, Laetitia; Cundari, Enrico; Leyns, Luc; Kirsch-Volders, Micheline.
Afiliación
  • Gonzalez L; Laboratory of Cell Genetics, Free University of Brussels (VUB), Brussels, Belgium.
  • Cundari E; Institute for Molecular Biology and Pathology, CNR, Rome, Italy.
  • Leyns L; Laboratory of Cell Genetics, Free University of Brussels (VUB), Brussels, Belgium.
  • Kirsch-Volders M; Laboratory of Cell Genetics, Free University of Brussels (VUB), Brussels, Belgium.
Basic Clin Pharmacol Toxicol ; 121 Suppl 3: 23-29, 2017 Sep.
Article en En | MEDLINE | ID: mdl-27813321
Changes in paradigm contribute to advances in research. The current paradigms for the evaluation of toxicity of chemicals refer to linear or curvilinear dose-response curves with or without threshold and to surface-dependent induction of oxidative damage for particles. The unique physicochemical properties and biological/genotoxic activity of engineered nanomaterials (NMs) require the development of a new paradigm. Because of their unusual dosimetry and their multiple interactions at NM level (agglomeration/aggregation) and at different cellular and extracellular levels, NMs are likely to have complex modes of action (multiple hits at multiple targets) leading to complex thresholded-non-thresholded dose-response curves. Understanding their cellular targets and their modes of action will contribute to the production of safe-by-design NMs. An integrative, cell-by-cell approach for genotoxic effects should be applied to tackle this emerging paradigm in nano-genotoxicology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Comunicación Celular / Especies Reactivas de Oxígeno / Nanoestructuras Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Basic Clin Pharmacol Toxicol Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Daño del ADN / Comunicación Celular / Especies Reactivas de Oxígeno / Nanoestructuras Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Basic Clin Pharmacol Toxicol Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido