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IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.
Dagdeviren, Sezin; Jung, Dae Young; Friedline, Randall H; Noh, Hye Lim; Kim, Jong Hun; Patel, Payal R; Tsitsilianos, Nicholas; Inashima, Kunikazu; Tran, Duy A; Hu, Xiaodi; Loubato, Marilia M; Craige, Siobhan M; Kwon, Jung Yeon; Lee, Ki Won; Kim, Jason K.
Afiliación
  • Dagdeviren S; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Jung DY; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Friedline RH; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Noh HL; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Kim JH; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Patel PR; Wellness Emergence Center, Advanced Institutes of Convergence Technology, Seoul National University, Suwon, South Korea.
  • Tsitsilianos N; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Inashima K; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Tran DA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Hu X; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Loubato MM; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Craige SM; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Kwon JY; Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Lee KW; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
  • Kim JK; Wellness Emergence Center, Advanced Institutes of Convergence Technology, Seoul National University, Suwon, South Korea.
FASEB J ; 31(2): 701-710, 2017 02.
Article en En | MEDLINE | ID: mdl-27811060
Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (MIL10) and in wild-type mice during hyperinsulinemic-euglycemic clamping. Despite similar fat mass and energy balance, MIL10 mice were protected from aging-associated insulin resistance with significant increases in glucose infusion rates, whole-body glucose turnover, and skeletal muscle glucose uptake (∼60%; P < 0.05), as compared to age-matched WT mice. This protective effect was associated with decreased muscle inflammation, but no changes in adipose tissue inflammation in aging MIL10 mice. These results demonstrate the importance of skeletal muscle inflammation in aging-mediated insulin resistance, and our findings further implicate a potential therapeutic role of anti-inflammatory cytokine in the treatment of aging-mediated insulin resistance.-Dagdeviren, S., Jung, D. Y., Friedline, R. H., Noh, H. L., Kim, J. H., Patel, P. R., Tsitsilianos, N., Inashima, K., Tran, D. A., Hu, X., Loubato, M. M., Craige, S. M., Kwon, J. Y., Lee, K. W., Kim, J. K. IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Resistencia a la Insulina / Interleucina-10 / Músculo Esquelético / Inflamación Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Resistencia a la Insulina / Interleucina-10 / Músculo Esquelético / Inflamación Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos