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Arterial Wall Perfusion Measured with Photon Counting Spectral X-ray CT.
Jorgensen, Steven M; Korinek, Mark J; Vercnocke, Andrew J; Anderson, Jill L; Halaweish, Ahmed; Leng, Shuai; McCollough, Cynthia H; Ritman, Erik L.
Afiliación
  • Jorgensen SM; Dept. of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN USA 55905.
  • Korinek MJ; Dept. of Physiology and Biomedical Engineering, Biomedical Imaging Resource, Mayo Clinic, 200 First Street SW, Rochester, MN USA 55905.
  • Vercnocke AJ; Dept. of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN USA 55905.
  • Anderson JL; Dept. of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN USA 55905.
  • Halaweish A; Siemens Healthcare, Malvern, PA USA 19355.
  • Leng S; Dept. Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN USA 55905.
  • McCollough CH; Dept. Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN USA 55905.
  • Ritman EL; Dept. of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, MN USA 55905.
Proc SPIE Int Soc Opt Eng ; 99672016 Aug 28.
Article en En | MEDLINE | ID: mdl-27807391
Early atherosclerosis changes perfusion of the arterial wall due to localized proliferation of the vasa vasorum. When contrast agent passes through the artery, some enters the vasa vasorum and increases radiopacity of the arterial wall. Technical challenges to detecting changes in vasa vasorum density include the thin arterial wall, partial volume averaging at the arterial lumen/wall interface and calcification within the wall. We used a photon-counting spectral CT scanner to study carotid arteries of anesthetized pigs and micro-CT of these arteries to quantify vasa vasorum density. The left carotid artery wall was injected with autologous blood to stimulate vasa vasorum angiogenesis. The scans were performed at 25-120 keV; the tube-current-time product was 550 mAs. A 60 mL bolus of iodine contrast agent was injected into the femoral vein at 5mL/s. Two seconds post injection, an axial scan was acquired at every 3 s over 60 s (i.e., 20 time points). Each time point acquired 28 contiguous transaxial slices with reconstructed voxels 0.16 × 0.16 × 1 mm3. Regions-of-interest in the outer 2/3 of the arterial wall and in the middle 2/3 of the lumen were drawn and their enhancements plotted versus time. Lumenal CT values peaked several seconds after injection and then returned towards baseline. Arterial wall CT values peaked concurrent to the lumen. The peak arterial wall enhancement in the left carotid arterial wall correlated with increased vasa vasorum density observed in micro-CT images of the isolated arteries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Proc SPIE Int Soc Opt Eng Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Proc SPIE Int Soc Opt Eng Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos