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Quorum sensing and microbial drug resistance.
Chen, Yu-fan; Liu, Shi-yin; Liang, Zhi-bin; Lv, Ming-fa; Zhou, Jia-nuan; Zhang, Lian-hui.
Afiliación
  • Chen YF; 1. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
  • Liu SY; 1. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
  • Liang ZB; 1. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
  • Lv MF; 1. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
  • Zhou JN; 1. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
  • Zhang LH; 1. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
Yi Chuan ; 38(10): 881-893, 2016 10 20.
Article en En | MEDLINE | ID: mdl-27806929
Microbial drug resistance has become a serious problem of global concern, and the evolution and regulatory mechanisms of microbial drug resistance has become a hotspot of research in recent years. Recent studies showed that certain microbial resistance mechanisms are regulated by quorum sensing system. Quorum sensing is a ubiquitous cell-cell communication system in the microbial world, which associates with cell density. High-density microbial cells produce sufficient amount of small signal molecules, activating a range of downstream cellular processes including virulence and drug resistance mechanisms, which increases bacterial drug tolerance and causes infections on host organisms. In this review, the general mechanisms of microbial drug resistance and quorum-sensing systems are summarized with a focus on the association of quorum sensing and chemical signaling systems with microbial drug resistance mechanisms, including biofilm formation and drug efflux pump. The potential use of quorum quenching as a new strategy to control microbial resistance is also discussed.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Farmacorresistencia Bacteriana / Percepción de Quorum / Antibacterianos Límite: Animals / Humans Idioma: En Revista: Yi Chuan Asunto de la revista: GENETICA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Farmacorresistencia Bacteriana / Percepción de Quorum / Antibacterianos Límite: Animals / Humans Idioma: En Revista: Yi Chuan Asunto de la revista: GENETICA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: China