Your browser doesn't support javascript.
loading
Relationship between cigarette smoking and risk of chronic myeloid leukaemia: a meta-analysis of epidemiological studies.
Qin, Ling; Deng, Hui-Yang; Chen, Sheng-Jiang; Wei, Wei.
Afiliación
  • Qin L; a Department of Hematology, First Affiliated Hospital, College of Clinical Medicine , Henan University of Science and Technology , Luoyang , Henan , China.
  • Deng HY; a Department of Hematology, First Affiliated Hospital, College of Clinical Medicine , Henan University of Science and Technology , Luoyang , Henan , China.
  • Chen SJ; b Department of Ultrasound, First Affiliated Hospital, College of Clinical Medicine , Henan University of Science and Technology , Luoyang , Henan , China.
  • Wei W; a Department of Hematology, First Affiliated Hospital, College of Clinical Medicine , Henan University of Science and Technology , Luoyang , Henan , China.
Hematology ; 22(4): 193-200, 2017 May.
Article en En | MEDLINE | ID: mdl-27806681
OBJECTIVE: Previous epidemiologic studies that have been reported on the association between cigarette smoking and risk of chronic myeloid leukaemia (CML) have remained controversial. A comprehensive meta-analysis was performed to evaluate smoking as a potential relationship factor and incidence of CML. METHODS: Systematic literatures collected from articles published before August 2015 were searched from PubMed, EMBASE and the Cochrane Library. A total of 10 studies (nine case-controls and one cohort) met inclusion criteria of this meta-analysis. Odds ratios (ORs) with 95% confidence interval (CI) were calculated to assess the strength of the association between cigarette smoking and risk of CML in this study. Quality assessments were performed on the studies with the Newcastle-Ottawa Scale. I2 index was used to evaluate heterogeneity. Finally, publication bias was assessed through funnel plots and Begger's test. RESULTS: No significant association was observed between ever-smokers and CML when compared among non-smokers (OR = 1.13, 95% CI: 0.99-1.29) or between subgroups stratified by smoking history, gender, geographical region, study design and source of patients. Our results demonstrate that this association was stronger in individuals who smoked <20 cigarettes/day (OR = 1.72, 95% CI: 1.06-2.79) vs. individuals who smoked >20 cigarettes/day (OR = 1.24, 95% CI: 0.55-2.81). Moreover, cumulative smoking of <15, 15-30 and >30 pack-years was associated with ORs of 1.22, 1.32 and 1.39, respectively (P < 0.001, for trend). CONCLUSION: This meta-analysis suggests that smoking may significantly increase the risk of CML in a dose-dependent manner. However, additional well-designed, prospective cohort studies are required to verify these findings and identify other risk factors associated with CML.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Fumar Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Hematology Asunto de la revista: HEMATOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mielógena Crónica BCR-ABL Positiva / Fumar Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Hematology Asunto de la revista: HEMATOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido