Inhibition of interferon-alpha/beta induction in L-929 cells by benzene and benzene metabolites.
Oncology
; 46(5): 335-8, 1989.
Article
en En
| MEDLINE
| ID: mdl-2779948
Murine L-929 cells were treated with benzene or a series of benzene metabolites, washed and then interferon-alpha/beta was induced with polyriboinosinic-polyribocytidylic acid. Exposure of the cells to benzene or phenol, a monocyclic metabolite of benzene, did not affect interferon-alpha/beta induction. However, exposure of the cells to p-benzoquinone, hydroquinone or catechol, dihydroxy- and diketo-metabolites of benzene, resulted in a severe inhibition of interferon-alpha/beta production. There was no significant loss of viability of the cell cultures. Additional studies with p-benzoquinone indicated that inhibition of interferon-alpha/beta was reversible and could be abrogated by addition of reduced glutathione to the cell cultures.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benceno
/
Derivados del Benceno
/
Interferón Tipo I
/
Benzoquinonas
Límite:
Animals
Idioma:
En
Revista:
Oncology
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Suiza