Your browser doesn't support javascript.
loading
Impact of combined lipid lowering and blood pressure control on coronary plaque: myocardial ischemia treated by percutaneous coronary intervention and plaque regression by lipid lowering and blood pressure controlling assessed by intravascular ultrasonography (MILLION) study.
Kawashiri, Masa-Aki; Sakata, Kenji; Hayashi, Kenshi; Gamou, Tadatsugu; Kanaya, Honin; Miwa, Kenji; Ueda, Kosei; Higashikata, Toshinori; Mizuno, Sumio; Michishita, Ichiro; Namura, Masanobu; Nitta, Yutaka; Katsuda, Shoji; Okeie, Kazuyasu; Hirase, Hiroaki; Tada, Hayato; Uchiyama, Katsuharu; Konno, Tetsuo; Ino, Hidekazu; Nagase, Keisuke; Yamagishi, Masakazu.
Afiliación
  • Kawashiri MA; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
  • Sakata K; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
  • Hayashi K; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
  • Gamou T; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
  • Kanaya H; Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
  • Miwa K; Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan.
  • Ueda K; Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan.
  • Higashikata T; Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan.
  • Mizuno S; Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan.
  • Michishita I; Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan.
  • Namura M; Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan.
  • Nitta Y; Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan.
  • Katsuda S; Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan.
  • Okeie K; Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan.
  • Hirase H; Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan.
  • Tada H; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
  • Uchiyama K; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
  • Konno T; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
  • Ino H; Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan.
  • Nagase K; Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
  • Yamagishi M; Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, 920-8641, Japan. myamagi@med.kanazawa-u.ac.jp.
Heart Vessels ; 32(5): 539-548, 2017 May.
Article en En | MEDLINE | ID: mdl-27798731
The aim of the study was to elucidate the aggressive reduction of both low-density lipoprotein cholesterol (LDL-C) and blood pressure (BP) reduced coronary atherosclerotic plaque volume compared with a standard treatment of LDL-C and BP in Japanese patients with coronary artery disease (CAD). This study is a prospective, randomized, and open-labelled with a blind-endpoint evaluation study. A total of 97 patients (81 men, mean age 62.0 ± 9.6) with CAD undergoing intravascular ultrasonography (IVUS)-guided percutaneous coronary intervention (PCI) were randomized, and 68 patients had IVUS examinations at baseline and at 18-24 months follow-up. Patients were randomly assigned to standard or aggressive strategies targeting LDL-C and a BP of 100 mg/dL and 140/90 mmHg vs. 70 mg/dL and 120/70 mmHg, respectively. The primary endpoint was the percent change in coronary plaque volume. Both standard and aggressive strategies succeeded to achieve target levels of LDL-C and BP; 74.9 ± 14.7 vs. 63.7 ± 11.9 mg/dL (NS) and 124.1 ± 9.4/75.8 ± 7.7 vs. 113.6 ± 9.6/65.8 ± 9.4 mmHg (systolic BP; NS, diastolic BP; p < 0.05), respectively. Both groups showed a significant reduction in the coronary plaque volume of -9.4 ± 10.7% and -8.7 ± 8.6% (NS) in standard and aggressive therapies, respectively. Both standard and aggressive intervention significantly regressed coronary plaque volume by the same degree, suggesting the importance of simultaneous reductions of LDL-C and BP for prevention of CAD.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Enfermedad de la Arteria Coronaria / Isquemia Miocárdica / Ultrasonografía Intervencional / Placa Aterosclerótica / Intervención Coronaria Percutánea / Antihipertensivos / Hipolipemiantes Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Heart Vessels Asunto de la revista: CARDIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Presión Sanguínea / Enfermedad de la Arteria Coronaria / Isquemia Miocárdica / Ultrasonografía Intervencional / Placa Aterosclerótica / Intervención Coronaria Percutánea / Antihipertensivos / Hipolipemiantes Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Heart Vessels Asunto de la revista: CARDIOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón