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An actigraphy study investigating sleep in bipolar I patients, unaffected siblings and controls.
Verkooijen, Sanne; van Bergen, Annet H; Knapen, Stefan E; Vreeker, Annabel; Abramovic, Lucija; Pagani, Lucia; Jung, Yoon; Riemersma-van der Lek, Rixt; Schoevers, Robert A; Takahashi, Joseph S; Kahn, René S; Boks, Marco P M; Ophoff, Roel A.
Afiliación
  • Verkooijen S; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: S.Verkooijen@umcutrecht.nl.
  • van Bergen AH; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Knapen SE; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Vreeker A; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Netherlands Institute of Mental Health and Addiction (Trimbos Institute), Drug Information and Monitoring System, Department of Drug Monitoring, Utrecht, The Netherlands; Department of
  • Abramovic L; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Pagani L; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Jung Y; Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USA.
  • Riemersma-van der Lek R; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Lentis FACT, Winschoten, The Netherlands.
  • Schoevers RA; Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Takahashi JS; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Kahn RS; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Boks MPM; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Ophoff RA; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, CA, USA.
J Affect Disord ; 208: 248-254, 2017 Jan 15.
Article en En | MEDLINE | ID: mdl-27792970
OBJECTIVES: Disturbances in sleep and waking patterns are highly prevalent during mood episodes in bipolar disorder. The question remains whether these disturbances persist during phases of euthymia and whether they are heritable traits of bipolar disorder. The current study investigates objective sleep measures in a large sample of bipolar I patients, non-affected siblings and controls. METHODS: A total of 107 bipolar disorder I patients, 74 non-affected siblings, and 80 controls were included. Sleep was measured with actigraphy over the course of 14 days. Seven sleep parameters were analyzed for group differences and their relationship with age at onset, number of episodes and psychotic symptoms using linear mixed model analysis to account for family dependencies. RESULTS: Patients had a longer sleep duration and later time of sleep offset compared to the non-affected siblings but these differences were entirely attributable to differences in mood symptoms. We found no difference between patients and controls or siblings and controls when the analyses were restricted to euthymic patients. None of the bipolar illness characteristics were associated with sleep. LIMITATIONS: Medication use was not taken into account which may have influenced our findings and controls were younger compared to non-affected siblings. CONCLUSIONS: In the largest study to date, our findings suggest that recovered bipolar I patients and their siblings do not experience clinically significant sleep disturbances. Sleep disturbances are primarily a reflection of current mood state, but are unrelated to the course of the disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Trastornos del Sueño-Vigilia / Trastorno Bipolar Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Trastornos del Sueño-Vigilia / Trastorno Bipolar Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos