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Potential relevance of microRNAs in inter-species epigenetic communication, and implications for disease pathogenesis.
Perge, Pál; Nagy, Zoltán; Decmann, Ábel; Igaz, Ivan; Igaz, Peter.
Afiliación
  • Perge P; a 2nd Department of Medicine, Faculty of Medicine , Semmelweis University , Budapest , Hungary.
  • Nagy Z; a 2nd Department of Medicine, Faculty of Medicine , Semmelweis University , Budapest , Hungary.
  • Decmann Á; a 2nd Department of Medicine, Faculty of Medicine , Semmelweis University , Budapest , Hungary.
  • Igaz I; b Department of Gastroenterology , Szent Imre Teaching Hospital , Budapest , Hungary.
  • Igaz P; a 2nd Department of Medicine, Faculty of Medicine , Semmelweis University , Budapest , Hungary.
RNA Biol ; 14(4): 391-401, 2017 04 03.
Article en En | MEDLINE | ID: mdl-27791594
MicroRNAs are short non-protein coding RNA molecules involved in the epigenetic regulation of gene expression. Recently, extracellular microRNAs have been described in body fluids that might enable epigenetic communication between distant tissues. Being highly conserved molecules, exogenous xeno-microRNAs from different species could affect gene expression in the host even in a cross-kingdom fashion. Several data underline the relevance of microRNA-mediated communication between virus and host, and there are some experimental data showing that plant- or animal-derived dietary microRNAs might have gene expression modulating activity in humans. Milk-derived microRNAs might be involved in the "epigenetic priming" of the baby. Exogenous microRNAs might be hypothesized to be implicated in disease pathogenesis, e.g. in tumors. Major questions remain to be addressed including the amount of xeno-microRNAs needed for biological action or routes for microRNA delivery. In this brief review, experimental data and hypotheses on the potential pathogenic inter-species relevance of microRNA are presented.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / MicroARNs / Epigénesis Genética Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: RNA Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Predisposición Genética a la Enfermedad / MicroARNs / Epigénesis Genética Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: RNA Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos