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Community deworming alleviates geohelminth-induced immune hyporesponsiveness.
Wammes, Linda J; Hamid, Firdaus; Wiria, Aprilianto Eddy; May, Linda; Kaisar, Maria M M; Prasetyani-Gieseler, Margaretta A; Djuardi, Yenny; Wibowo, Heri; Kruize, Yvonne C M; Verweij, Jaco J; de Jong, Sanne E; Tsonaka, Roula; Houwing-Duistermaat, Jeanine J; Sartono, Erliyani; Luty, Adrian J F; Supali, Taniawati; Yazdanbakhsh, Maria.
Afiliación
  • Wammes LJ; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Hamid F; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Wiria AE; Department of Microbiology, Faculty of Medicine, Hasanuddin University, 90245 Makassar, Indonesia.
  • May L; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Kaisar MM; Department of Parasitology, Faculty of Medicine, University of Indonesia, 10430 Jakarta, Indonesia.
  • Prasetyani-Gieseler MA; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Djuardi Y; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Wibowo H; Department of Parasitology, Faculty of Medicine, University of Indonesia, 10430 Jakarta, Indonesia.
  • Kruize YC; Department of Parasitology, Faculty of Medicine, University of Indonesia, 10430 Jakarta, Indonesia.
  • Verweij JJ; Department of Parasitology, Faculty of Medicine, University of Indonesia, 10430 Jakarta, Indonesia.
  • de Jong SE; Department of Parasitology, Faculty of Medicine, University of Indonesia, 10430 Jakarta, Indonesia.
  • Tsonaka R; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Houwing-Duistermaat JJ; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Sartono E; Laboratory for Medical Microbiology and Immunology, St. Elisabeth Ziekenhuis, 5022 GC Tilburg, The Netherlands.
  • Luty AJ; Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Supali T; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
  • Yazdanbakhsh M; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Proc Natl Acad Sci U S A ; 113(44): 12526-12531, 2016 11 01.
Article en En | MEDLINE | ID: mdl-27791067
In cross-sectional studies, chronic helminth infections have been associated with immunological hyporesponsiveness that can affect responses to unrelated antigens. To study the immunological effects of deworming, we conducted a cluster-randomized, double-blind, placebo-controlled trial in Indonesia and assigned 954 households to receive albendazole or placebo once every 3 mo for 2 y. Helminth-specific and nonspecific whole-blood cytokine responses were assessed in 1,059 subjects of all ages, whereas phenotyping of regulatory molecules was undertaken in 121 school-aged children. All measurements were performed before and at 9 and 21 mo after initiation of treatment. Anthelmintic treatment resulted in significant increases in proinflammatory cytokine responses to Plasmodium falciparum-infected red blood cells (PfRBCs) and mitogen, with the largest effect on TNF responses to PfRBCs at 9 mo-estimate [95% confidence interval], 0.37 [0.21-0.53], P value over time (Ptime) < 0.0001. Although the frequency of regulatory T cells did not change after treatment, there was a significant decline in the expression of the inhibitory molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) on CD4+ T cells of albendazole-treated individuals, -0.060 [-0.107 to -0.013] and -0.057 [-0.105 to -0.008] at 9 and 21 mo, respectively; Ptime = 0.017. This trial shows the capacity of helminths to up-regulate inhibitory molecules and to suppress proinflammatory immune responses in humans. This could help to explain the inferior immunological responses to vaccines and lower prevalence of inflammatory diseases in low- compared with high-income countries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Albendazol / Infecciones Comunitarias Adquiridas / Helmintiasis / Helmintos Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Albendazol / Infecciones Comunitarias Adquiridas / Helmintiasis / Helmintos Tipo de estudio: Clinical_trials / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Animals / Child / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2016 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos