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Relations between three dopaminergic system genes, school attachment, and adolescent delinquency.
Fine, Adam; Mahler, Alissa; Simmons, Cortney; Chen, Chuansheng; Moyzis, Robert; Cauffman, Elizabeth.
Afiliación
  • Fine A; Department of Psychology and Social Behavior, University of California, Irvine.
  • Mahler A; Department of Psychology and Social Behavior, University of California, Irvine.
  • Simmons C; Department of Psychology and Social Behavior, University of California, Irvine.
  • Chen C; Department of Psychology and Social Behavior, University of California, Irvine.
  • Moyzis R; Department of Biological Chemistry, University of California, Irvine.
  • Cauffman E; Department of Psychology and Social Behavior, University of California, Irvine.
Dev Psychol ; 52(11): 1893-1903, 2016 11.
Article en En | MEDLINE | ID: mdl-27786532
Both environmental factors and genetic variation, particularly in genes responsible for the dopaminergic system such as DRD4, DRD2, and DAT1 (SLC6A3), affect adolescent delinquency. The school context, despite its developmental importance, has been overlooked in gene-environment research. Using data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development (NICHD ECCYD), this study examined key interactions between school attachment and (a) each of the DRD4, DRD2, and DAT1 (SLC6A3) genotypes; and (b) a polygenic score. Results indicate that there is a main effect of school attachment, unlike genetic variation, on delinquency. Interestingly, there are important interactive effects of school attachment and dopaminergic genotypes on delinquency. Carriers of the DRD2-A1 allele were differentially affected by both positive and negative school environments, whereas DAT1-10R carriers fared the same as 9R homozygotes in poorer and moderate school environments, but fared disproportionately better in more positive environments. Contrary to expectations, youth without the DRD4-7R allele were particularly affected by the school environment. These findings contribute to the literature considering the roles of both context and genes in delinquency research, and inform our understanding of the individual-level traits that influence sensitivity to particular contexts. (PsycINFO Database Record
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Receptores de Dopamina D2 / Proteínas de Transporte de Dopamina a través de la Membrana Plasmática / Receptores de Dopamina D4 / Delincuencia Juvenil / Apego a Objetos Límite: Adolescent / Female / Humans / Male Idioma: En Revista: Dev Psychol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Receptores de Dopamina D2 / Proteínas de Transporte de Dopamina a través de la Membrana Plasmática / Receptores de Dopamina D4 / Delincuencia Juvenil / Apego a Objetos Límite: Adolescent / Female / Humans / Male Idioma: En Revista: Dev Psychol Año: 2016 Tipo del documento: Article Pais de publicación: Estados Unidos