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Cadmium-induced apoptosis of Siberian tiger fibroblasts via disrupted intracellular homeostasis.
Wang, Hui; Liu, Zheng; Zhang, Wenxiu; Yuan, Ziao; Yuan, Hongyi; Liu, Xueting; Yang, Chunwen; Guan, Weijun.
Afiliación
  • Wang H; Jinzhou Medical University, Jinzhou, 121001, China.
  • Liu Z; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Zhang W; Jinzhou Medical University, Jinzhou, 121001, China.
  • Yuan Z; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Yuan H; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Liu X; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Yang C; Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.
  • Guan W; College of Life Science and Technology, Mudanjiang Normal University, Mudanjiang, 157012, China.
Biol Res ; 49(1): 42, 2016 Oct 24.
Article en En | MEDLINE | ID: mdl-27776532
BACKGROUND: Heavy metals can cause great harm to Siberian tigers in the natural environment. Cadmium (Cd2+) is an environmental contaminant that affects multiple cellular processes, including cell proliferation, differentiation, and survival. It has been shown to induce apoptosis in a variety of cell types and tissues. RESULTS: We investigated the apoptotic effects of Cd2+ on Siberian tiger fibroblasts in vitro. Our research revealed the typical signs of apoptosis after Cd2+ exposure. Apoptosis was dose- (0-4.8 µM) and duration-dependent (12-48 h), and proliferation was strongly inhibited. Cd2+ increased the activity of caspase-3, -8, and -9 and disrupted calcium homeostasis by causing oxidative stress and mitochondrial dysfunction. It also increased K+ efflux and altered the mRNA levels of Bax, Bcl-2, caspase-3, caspase-8, Fas, and p53. CONCLUSIONS: Our results suggest that Cd2+ triggers the apoptosis of Siberian tiger fibroblasts by disturbing intracellular homeostasis. These results will aid in our understanding of the effects of Cd2+ on Siberian tigers and in developing interventions to treat and prevent cadmium poisoning.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Apoptosis / Espacio Intracelular / Tigres / Fibroblastos / Homeostasis Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Biol Res Asunto de la revista: BIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Apoptosis / Espacio Intracelular / Tigres / Fibroblastos / Homeostasis Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Biol Res Asunto de la revista: BIOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido