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Role of neurodevelopment involved genes in psychiatric comorbidities and modulation of inflammatory processes in Alzheimer's disease.
Porcelli, Stefano; Crisafulli, Concetta; Donato, Luigi; Calabrò, Marco; Politis, Antonis; Liappas, Ioannis; Albani, Diego; Atti, Anna Rita; Salfi, Raffaele; Raimondi, Ilaria; Forloni, Gianluigi; Papadimitriou, George N; De Ronchi, Diana; Serretti, Alessandro.
Afiliación
  • Porcelli S; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Crisafulli C; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina-, Italy.
  • Donato L; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina-, Italy.
  • Calabrò M; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina-, Italy.
  • Politis A; Department of Psychiatry, University of Athens Medical School, Eginition Hospital, Athens, Greece.
  • Liappas I; Department of Psychiatry, University of Athens Medical School, Eginition Hospital, Athens, Greece.
  • Albani D; IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Department of Neuroscience, Milan, Italy.
  • Atti AR; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Salfi R; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Raimondi I; IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Department of Neuroscience, Milan, Italy.
  • Forloni G; IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Department of Neuroscience, Milan, Italy.
  • Papadimitriou GN; Department of Psychiatry, University of Athens Medical School, Eginition Hospital, Athens, Greece.
  • De Ronchi D; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Serretti A; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy. Electronic address: alessandro.serretti@unibo.it.
J Neurol Sci ; 370: 162-166, 2016 11 15.
Article en En | MEDLINE | ID: mdl-27772752
INTRODUCTION: With the increase of the population's average age, Alzheimer's disease (AD) is becoming one of the most disabling diseases worldwide. Recently, neurodevelopment processes have been involved in the AD etiopathogenesis. Genetic studies in this field could contribute to our knowledge and suggest new molecular targets for possible treatments. METHODS: Our primary aim was to investigate the associations among single nucleotide polymorphisms (SNPs) within neurodevelopment related genes (BDNF, ST8SIA2, C15orf32, NCAPG2, ESYT2, WDR60, LOC154822, VIPR2, GSK3B, NR1I2, ZNF804A, SP4) and AD. A number of exploratory analyses was also performed to evaluate the associations with the presence of behavioral and psychiatric symptoms of dementia (BPSD), as well as with variations in hematological parameters. Two independent samples were investigated, one of 228 Greek subjects and one sample of 229 Italian subjects, including 156Alzheimer's Disease patients CE patients and 301 healthy controls. All patients were affected by late onset AD (LOAD). RESULTS: None of the analyzed SNPs was associated with AD in our samples. In the exploratory analyses, several genetic variants were associated with inflammation parameters in the Greek sample and in the merged one, suggesting a relationship among these genes and the modulation of inflammation and the immune response. Other exploratory analyses showed associations among several SNPs and psychiatric symptomatology in the Greek sample, suggesting a possible modulation of these variants on psychiatric comorbidities in AD. CONCLUSIONS: Although we failed to find a direct relationship between AD and the genetic variants investigated, possible connections with inflammation and psychiatric symptoms were suggested.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Enfermedad de Alzheimer / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Neurol Sci Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Enfermedad de Alzheimer / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Neurol Sci Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos