Evaluation of cytotoxic effect of the combination of a pyridinyl carboxamide derivative and oxaliplatin on NCI-H1299 human non-small cell lung carcinoma cells.

Teixeira, Sarah Fernandes; de Azevedo, Ricardo Alexandre; Silva, Arthur Carvalho; Braga, Rodolpho Campos; Jorge, Salomão Dória; Barbuto, José Alexandre Marzagão; Andrade, Carolina Horta; Ferreira, Adilson Kleber

Teixeira, Sarah Fernandes; de Azevedo, Ricardo Alexandre; Silva, Arthur Carvalho; Braga, Rodolpho Campos; Jorge, Salomão Dória; Barbuto, José Alexandre Marzagão; Andrade, Carolina Horta; Ferreira, Adilson Kleber.

Afiliación

Teixeira SF; Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, Prof. Lineu Prestes Avenue, 1730 Sao Paulo - SP, Brazil.
de Azevedo RA; Laboratory of Tumor Immunology, Department of Immunology, Institute of Biomedical Science, University of São Paulo, Prof. Lineu Prestes Avenue, 1730 Sao Paulo - SP, Brazil.
Silva AC; LabMol - Laboratory for Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goias, 240 Street, 74605-170, Goiania - GO, Brazil.
Braga RC; LabMol - Laboratory for Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goias, 240 Street, 74605-170, Goiania - GO, Brazil.
Jorge SD; Laboratory of Tumor Immunology, Department of Immunology, Institute of Biomedical Science, University of São Paulo, Prof. Lineu Prestes Avenue, 1730 Sao Paulo - SP, Brazil.
Barbuto JAM; Laboratory of Tumor Immunology, Department of Immunology, Institute of Biomedical Science, University of São Paulo, Prof. Lineu Prestes Avenue, 1730 Sao Paulo - SP, Brazil.
Andrade CH; LabMol - Laboratory for Molecular Modeling and Drug Design, Faculty of Pharmacy, Federal University of Goias, 240 Street, 74605-170, Goiania - GO, Brazil.
Ferreira AK; Laboratory of Tumor Immunology, Department of Immunology, Institute of Biomedical Science, University of São Paulo, Prof. Lineu Prestes Avenue, 1730 Sao Paulo - SP, Brazil. Electronic address: ferreira-kleber@usp.br.

Biomed Pharmacother ; 84: 1019-1028, 2016 Dec.

Article en En | MEDLINE | ID: mdl-27768927

Asunto(s)

Amidas/farmacología; Protocolos de Quimioterapia Combinada Antineoplásica/farmacología; Carcinoma de Pulmón de Células no Pequeñas/tratamiento farmacológico; Neoplasias Pulmonares/tratamiento farmacológico; Compuestos Organoplatinos/farmacología; Piridinas/farmacología; Apoptosis/efectos de los fármacos; Carcinoma de Pulmón de Células no Pequeñas/patología; Puntos de Control del Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Sinergismo Farmacológico; Humanos; Neoplasias Pulmonares/patología; Modelos Moleculares; Estructura Molecular; Oxaliplatino; Relación Estructura-Actividad

Palabras clave

Apoptosis; Lung cancer; Oxaliplatin; Pyridinyl carboxamide derivative; Synergism

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Organoplatinos / Piridinas / Protocolos de Quimioterapia Combinada Antineoplásica / Carcinoma de Pulmón de Células no Pequeñas / Amidas / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Francia

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