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Expression of CK19 is an independent predictor of negative outcome for patients with squamous cell carcinoma of the tongue.
Ernst, Jutta; Ikenberg, Kristian; Apel, Barbara; Schumann, Desiree M; Huber, Gerhard; Studer, Gabriela; Rordorf, Tamara; Riesterer, Oliver; Rössle, Matthias; Korol, Dimitri; Bredell, Marius G.
Afiliación
  • Ernst J; Department of Cranio-, Maxillofacial and Oral Surgery, University Hospital Zurich, Zürich, Switzerland.
  • Ikenberg K; Department of Pathology, University Hospital Zurich, Zürich, Switzerland.
  • Apel B; Department of Pathology, University Hospital Zurich, Zürich, Switzerland.
  • Schumann DM; Department of Cranio-, Maxillofacial and Oral Surgery, University Hospital Zurich, Zürich, Switzerland.
  • Huber G; Department of Otorhinolaryngology, University Hospital Zurich, Zürich, Switzerland.
  • Studer G; Department of Radiation Oncology, University Hospital Zurich, Zürich, Switzerland.
  • Rordorf T; Department of Oncology, University Hospital Zurich, Zürich, Switzerland.
  • Riesterer O; Department of Radiation Oncology, University Hospital Zurich, Zürich, Switzerland.
  • Rössle M; Department of Pathology, Cantonal Hospital Chur, Chur, Switzerland.
  • Korol D; Cancer Registry Zurich and Zug, University Hospital Zurich, Zürich, Switzerland.
  • Bredell MG; Department of Cranio-, Maxillofacial and Oral Surgery, University Hospital Zurich, Zürich, Switzerland.
Oncotarget ; 7(46): 76151-76158, 2016 Nov 15.
Article en En | MEDLINE | ID: mdl-27764819
OBJECTIVES: To explore the prognostic role of CK19 expression in squamous cell carcinomas within a well-defined cohort of oral tongue cancer patients. METHODS: In our retrospective study, we investigated 129 patients with tongue cancer that had suitable material for inclusion in a tissue microarray (TMA). Where possible, samples were taken from central and peripheral regions of the tumor to generate a representative sample of the tumor. The expression level of CK19 was assessed by immunohistochemical staining. RESULTS: Expression of CK19 in squamous cell carcinoma of the tongue was identified as a negative predictor for overall survival (OS; p<0.000) and disease specific survival (DSS; p=0.001). No significant difference could be shown for disease free survival (DFS) between patients with positive and negative CK19 staining (p=.094). CONCLUSION: This is the first description of the highly significant role of CK19 in a selective, organ specific head and neck cancer cohort. Our results are of special importance against the background that CK19 positive carcinomas revealed a significantly poorer prognosis and therefore emphasize its prognostic and possible diagnostic role in tongue cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Lengua / Carcinoma de Células Escamosas / Expresión Génica / Queratina-19 Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Lengua / Carcinoma de Células Escamosas / Expresión Génica / Queratina-19 Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Oncotarget Año: 2016 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos