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Autosomal Dominant Polycystic Disease is Associated with Depressed Levels of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand.
Sari, Funda; Yalçin, Arzu Didem; Genç, Gizem Esra; Sarikaya, Metin; Bisgin, Atil; Çetinkaya, Ramazan; Gümüslü, Saadet.
Afiliación
  • Sari F; Division of Nephrology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
  • Yalçin AD; Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
  • Genç GE; Department of Biochemistry, Akdeniz University School of Medicine, Antalya, Turkey.
  • Sarikaya M; Division of Nephrology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
  • Bisgin A; Department of Clinical and Experimental Medicine, University of Linköping School of Health Sciences, Linköping, Sweden.
  • Çetinkaya R; Division of Nephrology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya, Turkey.
  • Gümüslü S; Department of Biochemistry, Akdeniz University School of Medicine, Antalya, Turkey.
Balkan Med J ; 33(5): 512-516, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27761278
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by multiple, large renal cysts and impaired kidney function. Although the reason for the development of kidney cysts is unknown, ADPKD is associated with cell cycle arrest and abundant apoptosis of renal tubular epithelial cells. AIMS: We asked whether serum-soluble TNF-related apoptosis-inducing ligand (sTRAIL) might underlie ADPKD. STUDY DESIGN: Case-control study. METHODS: Serum sTRAIL levels were measured in 44 patients with ADPKD and 18 healthy volunteers. The human soluble TRAIL/Apo2L ELISA kit was used for the in vitro quantitative determination of sTRAIL in serum samples. RESULTS: Mean serum sTRAIL levels were lower in patients with ADPKD as compared to the control group (446.9±103.1 and 875.9±349.6 pg/mL, p<0.001). Serum sTRAIL levels did not differ among stages of renal failure in patients with ADPKD. There was no correlation between serum sTRAIL levels and estimated glomerular filtration rate in patients with ADPKD (p>0.05). CONCLUSION: Our results show that ADPKD patients have depressed sTRAIL levels, indicating apoptosis unrelated to the stage of chronic renal failure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Balkan Med J Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Balkan Med J Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Turquía