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Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology.
Liu, Ying; Zhang, Chaoting; Gao, Weijiao; Wang, Limin; Pan, Yaqi; Gao, Yunong; Lu, Zheming; Ke, Yang.
Afiliación
  • Liu Y; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Genetics, Peking University Cancer Hospital &Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China.
  • Zhang C; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Genetics, Peking University Cancer Hospital &Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China.
  • Gao W; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gynecologic Oncology, Peking University Cancer Hospital &Institute, No 52, Fucheng Road, Haidian District, Beijing 100142, China.
  • Wang L; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of clinical laboratory, Peking University Cancer Hospital &Institute, No 52, Fucheng Road, Haidian District, Beijing 100142, China.
  • Pan Y; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Genetics, Peking University Cancer Hospital &Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China.
  • Gao Y; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gynecologic Oncology, Peking University Cancer Hospital &Institute, No 52, Fucheng Road, Haidian District, Beijing 100142, China.
  • Lu Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital &Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China.
  • Ke Y; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Genetics, Peking University Cancer Hospital &Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China.
Sci Rep ; 6: 35427, 2016 10 19.
Article en En | MEDLINE | ID: mdl-27759101
HPV integration plays an important role in cervical carcinogenesis. HPV genotypes and the exact integration sites were investigated using HPV capture technology combined with next generation sequencing in 166 women. Three, one and six integration sites were verified in 7 HPV-positive 'normal cervical epithelium', 6 HPV-positive CIN2 and 15 HPV-positive CIN 3 samples, respectively. Of the 10 integrations, one and nine were involved with HPV33 and HPV16, respectively. Our study accurately evaluated HPV integration level in CINs and normal cervical tissues using high-throughput viral integration detection method providing basic evidence for HPV integration-driven cervical carcinogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papillomaviridae / ADN Viral / Displasia del Cuello del Útero / Integración Viral / Infecciones por Papillomavirus / Estudio de Asociación del Genoma Completo Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papillomaviridae / ADN Viral / Displasia del Cuello del Útero / Integración Viral / Infecciones por Papillomavirus / Estudio de Asociación del Genoma Completo Límite: Female / Humans Idioma: En Revista: Sci Rep Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido