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Detection of circulating tumour cells may add value in endometrial cancer management.
Ni, T; Sun, X; Shan, B; Wang, J; Liu, Y; Gu, S-L; Wang, Y-D.
Afiliación
  • Ni T; Department of Gynaecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Sun X; Laboratory of Gynaecologic Oncology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Shan B; Fudan University Shanghai Cancer Centre, Shanghai, China.
  • Wang J; Department of Gynaecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Liu Y; Department of Gynaecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Gu SL; Department of Gynaecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Wang YD; Department of Gynaecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: owangyudong@126.com.
Eur J Obstet Gynecol Reprod Biol ; 207: 1-4, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27756035
OBJECTIVE: To evaluate the role of circulating tumour cells (CTCs) in patients with endometrial cancer (EC). STUDY DESIGN: This study included 40 patients with a pre-operative diagnosis of high-risk EC between April 2015 and May 2016. Patients were further divided into high-risk (grade 3, non-endometrioid, myometrial invasion ≥1/2 and stage III-IV) and high-intermediate-risk (grade 2-3, endometrioid, myometrial invasion <1/2 and stage I-II) groups according to postoperative pathological results. CTCs were detected using the CellSearch system, and CTC results were correlated with standard clinicopathological characteristics and serum tumour marker CA125/HE4 status using Chi-squared test, continuity correction or Fisher's exact test. The pharmacodynamic effect was detected after the first cycle of adjuvant therapy. Patients were followed up for 13 months to assess outcomes. RESULTS: Fifteen percent of patients had one or more CTCs. The presence of CTCs was found to be significantly associated with cervical involvement (83.33% vs 11.76%, p=0.00). No significant difference in CTC-positive rates was detected between the high-risk and high-intermediate-risk groups, and no significant correlation was found between CTCs and serum CA125/HE4, either by positive rates or exact serum levels of the conventional tumour markers. No more CTCs were detected after the first cycle of standard chemotherapy in this study, and no distant metastases or recurrence were found in the CTC-positive patients during the follow-up period. CONCLUSION: The presence of CTCs was correlated with cervical involvement. Early-stage EC patients with CTCs may benefit from additional adjuvant therapies. Assessment of CTCs may be useful in the management of high-risk EC patients.
Asunto(s)
Cuello del Útero/patología; Neoplasias Endometriales/sangre; Endometrio/patología; Miometrio/patología; Células Neoplásicas Circulantes/patología; Neoplasias del Cuello Uterino/secundario; Neoplasias Uterinas/secundario; Adulto; Anciano; Biomarcadores de Tumor/sangre; Antígeno Ca-125/sangre; Carcinoma Endometrioide/sangre; Carcinoma Endometrioide/patología; Carcinoma Endometrioide/secundario; Carcinoma Endometrioide/terapia; Cuello del Útero/efectos de los fármacos; Cuello del Útero/cirugía; Quimioterapia Adyuvante; Cistadenocarcinoma Seroso/sangre; Cistadenocarcinoma Seroso/patología; Cistadenocarcinoma Seroso/secundario; Cistadenocarcinoma Seroso/terapia; Neoplasias Endometriales/patología; Neoplasias Endometriales/prevención & control; Neoplasias Endometriales/terapia; Endometrio/efectos de los fármacos; Endometrio/cirugía; Femenino; Estudios de Seguimiento; Humanos; Proteínas de la Membrana/sangre; Persona de Mediana Edad; Miometrio/efectos de los fármacos; Miometrio/cirugía; Clasificación del Tumor; Invasividad Neoplásica; Recurrencia Local de Neoplasia/prevención & control; Estadificación de Neoplasias; Células Neoplásicas Circulantes/efectos de los fármacos; Proteínas/análisis; Neoplasias del Cuello Uterino/tratamiento farmacológico; Neoplasias del Cuello Uterino/prevención & control; Neoplasias del Cuello Uterino/cirugía; Neoplasias Uterinas/tratamiento farmacológico; Neoplasias Uterinas/prevención & control; Neoplasias Uterinas/cirugía; Proteína 2 de Dominio del Núcleo de Cuatro Disulfuros WAP
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Uterinas / Neoplasias del Cuello Uterino / Cuello del Útero / Neoplasias Endometriales / Endometrio / Miometrio / Células Neoplásicas Circulantes Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Uterinas / Neoplasias del Cuello Uterino / Cuello del Útero / Neoplasias Endometriales / Endometrio / Miometrio / Células Neoplásicas Circulantes Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Irlanda