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4-phenylselenyl-7-chloroquinoline, a novel multitarget compound with anxiolytic activity: Contribution of the glutamatergic system.
Reis, Angélica S; Pinz, Mikaela; Duarte, Luis Fernando B; Roehrs, Juliano A; Alves, Diego; Luchese, Cristiane; Wilhelm, Ethel A.
Afiliación
  • Reis AS; Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica, Grupo de Pesquisa em Neurobiotecnologia - GPN, CCQFA Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brasil.
  • Pinz M; Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica, Grupo de Pesquisa em Neurobiotecnologia - GPN, CCQFA Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brasil.
  • Duarte LFB; Programa de Pós-Graduação em Química, Laboratório de Síntese Orgânica Limpa - LASOL, CCQFA, Universidade Federal de Pelotas, UFPel, P.O. Box 354, 96010-900, Pelotas, RS, Brasil.
  • Roehrs JA; Programa de Pós-Graduação em Química, Laboratório de Síntese Orgânica Limpa - LASOL, CCQFA, Universidade Federal de Pelotas, UFPel, P.O. Box 354, 96010-900, Pelotas, RS, Brasil.
  • Alves D; Programa de Pós-Graduação em Química, Laboratório de Síntese Orgânica Limpa - LASOL, CCQFA, Universidade Federal de Pelotas, UFPel, P.O. Box 354, 96010-900, Pelotas, RS, Brasil.
  • Luchese C; Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica, Grupo de Pesquisa em Neurobiotecnologia - GPN, CCQFA Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brasil. Electronic address: cristiane_luchese@yahoo.com.br.
  • Wilhelm EA; Programa de Pós-Graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa em Farmacologia Bioquímica, Grupo de Pesquisa em Neurobiotecnologia - GPN, CCQFA Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brasil. Electronic address: ethelwilhelm@yahoo.com.br.
J Psychiatr Res ; 84: 191-199, 2017 01.
Article en En | MEDLINE | ID: mdl-27756019
A growing body of evidence demonstrates that quinoline compounds have attracted much attention in the field of drug development. Accordingly, 4-phenylselenyl-7-chloroquinoline (4-PSQ) is a new quinoline derivative containing selenium, which showed a potential antioxidant, antinociceptive and anti-inflammatory effect. The present study was undertaken to evaluate the anxiolytic-like properties of 4-PSQ. Mice were orally pretreated with 4-PSQ (5-50 mg/kg) or vehicle, 30 min prior to the elevated plus-maze (EPM), light-dark (LDT) or open field (OFT) tests. A time-response curve was carried out by administration of 4-PSQ (50 mg/kg) at different times before the EPM test. The involvement of glutamate uptake/release and Na+, K+-ATPase activity in the anxiolytic-like effect was investigated in cerebral cortices. In addition, the effectiveness of acute treatment with 4-PSQ was evaluated in a model of kainate (KA)-induced anxiety-related behavior. Finally, acute toxicity of this compound was investigated. 4-PSQ produced an anxiolytic-like action, both in EPM and LDT. In OFT, 4-PSQ did not affect locomotor and exploratory activities. 4-PSQ anxiolytic-like effect started at 0.5 h and remained significant up to 72 h after administration. Treatment with 4-PSQ reduced [3H] glutamate uptake, but the [3H] glutamate release and Na+, K+-ATPase activity were not altered. KA-induced anxiety-related behavior was protected by 4-PSQ pretreatment. Additionally, 4-PSQ exposure did not alter urea levels, aspartate (AST) and alanine aminotrasferase (ALT) activities in plasma. Parameters of oxidative stress in brain and liver of mice were not modified by 4-PSQ. Taken together these data demonstrated that the anxiolytic-like effect caused by 4-PSQ seems to be mediated by involvement of the glutamatergic system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Quinolinas / Ansiolíticos / Compuestos de Organoselenio / Fármacos actuantes sobre Aminoácidos Excitadores Tipo de estudio: Prognostic_studies Idioma: En Revista: J Psychiatr Res Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Quinolinas / Ansiolíticos / Compuestos de Organoselenio / Fármacos actuantes sobre Aminoácidos Excitadores Tipo de estudio: Prognostic_studies Idioma: En Revista: J Psychiatr Res Año: 2017 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido