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Bacterial etiology of sexually transmitted infections at a STI clinic in Ghana; use of multiplex real time PCR.
Sylverken, Augustina A; Owusu-Dabo, Ellis; Yar, Denis D; Salifu, Samson P; Awua-Boateng, Nana Yaa; Amuasi, John H; Okyere, Portia B; Agyarko-Poku, Thomas.
Afiliación
  • Sylverken AA; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana; Department of Theoretical and Applied Biology, KNUST, Kumasi, Ghana.
  • Owusu-Dabo E; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana; School of Public Health, KNUST, Kumasi, Ghana.
  • Yar DD; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
  • Salifu SP; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana; Department of Biochemistry and Biotechnology, KNUST, Kumasi, Ghana.
  • Awua-Boateng NY; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
  • Amuasi JH; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
  • Okyere PB; Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
  • Agyarko-Poku T; Suntreso Government Hospital, Ghana Health Services, Kumasi, Ghana.
Ghana Med J ; 50(3): 142-148, 2016 Sep.
Article en En | MEDLINE | ID: mdl-27752188
BACKGROUND: Most sexually transmitted infection (STI) management efforts focus on the syndromic approach to diagnose and treat patients. However, most women with STIs have been shown to be entirely asymptomatic, or if symptoms exist, are often missed when either clinical or conventional bacteriologic diagnostic tools are employed. METHODS: We assessed the performance of a multiplex real time PCR assay to describe other potential pathogens that could be missed by conventional bacteriological techniques in 200 women attending a routine STI clinic in Kumasi, Ghana. RESULTS: Although a total 78.00% of the women were asymptomatic, 77.1% of them tested positive for at least one bacterial STI pathogen. Mycoplasma genitalium was the most commonly detectable pathogen present in 67.5% of all women. Of those testing positive, 25.0% had single infections, while 38.0% and 19.5% had double and triple infections respectively. Altogether, 86.54% and 90.91% of the symptomatic and asymptomatic women respectively tested positive for at least one pathogen (p<0.05). There were no significant associations (p<0.05) between the clinical manifestations of the symptomatic women and the pathogens detected in their samples. CONCLUSIONS: Our study confirmed the importance of complementing the syndromic approach to STI management with pathogen detection and most importantly recognise that STIs in women are asymptomatic and regular empirical testing even for both symptomatic and asymptomatic patients is critical for complete clinical treatment. FUNDING: EOD (Ellis Owusu-Dabo Research working group, KCCR).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Bacterianas de Transmisión Sexual / Mycoplasma genitalium / Reacción en Cadena de la Polimerasa Multiplex / Infecciones por Mycoplasma Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Middle aged País/Región como asunto: Africa Idioma: En Revista: Ghana Med J Año: 2016 Tipo del documento: Article País de afiliación: Ghana Pais de publicación: Ghana
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Bacterianas de Transmisión Sexual / Mycoplasma genitalium / Reacción en Cadena de la Polimerasa Multiplex / Infecciones por Mycoplasma Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adolescent / Adult / Aged / Child / Female / Humans / Middle aged País/Región como asunto: Africa Idioma: En Revista: Ghana Med J Año: 2016 Tipo del documento: Article País de afiliación: Ghana Pais de publicación: Ghana