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Common variants in the chromosome 2p23 region containing the SLC30A3 (ZnT3) gene are associated with schizophrenia in female but not male individuals in a large collection of European samples.
Perez-Becerril, C; Morris, A G; Mortimer, A; McKenna, P J; de Belleroche, J.
Afiliación
  • Perez-Becerril C; Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK. Electronic address: c.perez06@imperial.ac.uk.
  • Morris AG; Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK. Electronic address: a.morris@imperial.ac.uk.
  • Mortimer A; University of Hull and NAViGO, Hull, UK. Electronic address: ann.mortimer@nhs.net.
  • McKenna PJ; Benito Menni Complex Assistencial en Salut Mental, Germanes Hospitalàries del Sagrat Cor de Jesús, C/Doctor Antoni Pujades 38-C, 08830 Sant Boi de Llobregat Barcelona, Spain. Electronic address: pmckenna@fidmag.com.
  • de Belleroche J; Neurogenetics Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK. Electronic address: j.belleroche@imperial.ac.uk.
Psychiatry Res ; 246: 335-340, 2016 Dec 30.
Article en En | MEDLINE | ID: mdl-27750116
Previously, we found a significant gender-specific association of schizophrenia, in a UK case/control study, with SLC30A3, a candidate that is consistently down-regulated in schizophrenia in two independent cohorts. In view of the potential significance of this finding, we extended this study to a larger cohort using GWAS data from the Psychiatric Genetic Consortium (PGC). Meta-analysis was performed for the only two SLC30A3 SNP variants (rs11126936 and rs11126929) available in most PGC cohorts. A significant association with schizophrenia was found for both variants. When meta-analysis was performed in male and female case-control subsets, an increased and gender-specific effect of allele on risk of disease was found in females for both SNPs with no significant effect in males, which was further associated with a gender-specific effect on gene expression. In conclusion, using a large European-wide sample we were able to replicate the gender-specific association previously found in a UK cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Proteínas de Transporte de Catión / Estudio de Asociación del Genoma Completo Tipo de estudio: Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Psychiatry Res Año: 2016 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Proteínas de Transporte de Catión / Estudio de Asociación del Genoma Completo Tipo de estudio: Observational_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Psychiatry Res Año: 2016 Tipo del documento: Article Pais de publicación: Irlanda