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Structural and conformational determinants of macrocycle cell permeability.
Over, Björn; Matsson, Pär; Tyrchan, Christian; Artursson, Per; Doak, Bradley C; Foley, Michael A; Hilgendorf, Constanze; Johnston, Stephen E; Lee, Maurice D; Lewis, Richard J; McCarren, Patrick; Muncipinto, Giovanni; Norinder, Ulf; Perry, Matthew W D; Duvall, Jeremy R; Kihlberg, Jan.
Afiliación
  • Over B; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.
  • Matsson P; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
  • Tyrchan C; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Artursson P; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.
  • Doak BC; Department of Pharmacy, Uppsala University, Uppsala, Sweden.
  • Foley MA; Uppsala University Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), a node at the Chemical Biology Consortium Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Hilgendorf C; Department of Chemistry, Uppsala University, Uppsala, Sweden.
  • Johnston SE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
  • Lee MD; Drug Safety and Metabolism, Safety &ADME Translational Sciences, AstraZeneca R&D Gothenburg, Mölndal, Sweden.
  • Lewis RJ; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
  • McCarren P; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
  • Muncipinto G; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.
  • Norinder U; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
  • Perry MW; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, USA.
  • Duvall JR; Swedish Toxicology Sciences Research Center, Södertälje, Sweden.
  • Kihlberg J; Respiratory, Inflammation and Autoimmunity Diseases, Innovative Medicines and Early Development Biotech Unit, AstraZeneca R&D Gothenburg, Mölndal, Sweden.
Nat Chem Biol ; 12(12): 1065-1074, 2016 12.
Article en En | MEDLINE | ID: mdl-27748751
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Macrocíclicos Límite: Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos Macrocíclicos Límite: Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Estados Unidos