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Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults.
Campbell, Peter T; Newton, Christina C; Freedman, Neal D; Koshiol, Jill; Alavanja, Michael C; Beane Freeman, Laura E; Buring, Julie E; Chan, Andrew T; Chong, Dawn Q; Datta, Mridul; Gaudet, Mia M; Gaziano, J Michael; Giovannucci, Edward L; Graubard, Barry I; Hollenbeck, Albert R; King, Lindsey; Lee, I-Min; Linet, Martha S; Palmer, Julie R; Petrick, Jessica L; Poynter, Jenny N; Purdue, Mark P; Robien, Kim; Rosenberg, Lynn; Sahasrabuddhe, Vikrant V; Schairer, Catherine; Sesso, Howard D; Sigurdson, Alice J; Stevens, Victoria L; Wactawski-Wende, Jean; Zeleniuch-Jacquotte, Anne; Renehan, Andrew G; McGlynn, Katherine A.
Afiliación
  • Campbell PT; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia. peter.campbell@cancer.org.
  • Newton CC; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
  • Freedman ND; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Koshiol J; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Alavanja MC; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Beane Freeman LE; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Buring JE; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
  • Chan AT; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Chong DQ; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Division of Medical Oncology, National Cancer Centre Singapore, Singapore.
  • Datta M; Department of Nutrition Science, Purdue University, West Lafayette, Indiana.
  • Gaudet MM; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
  • Gaziano JM; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. VA Boston Healthcare System, Boston, Massachusetts.
  • Giovannucci EL; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts. Department of Nutrition, Harvard TH Chan School of Public Health, Boston, Massachusetts.
  • Graubard BI; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Hollenbeck AR; AARP, Washington, DC (retired).
  • King L; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
  • Lee IM; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
  • Linet MS; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Palmer JR; Slone Epidemiology Center at Boston University, Boston, Massachusetts.
  • Petrick JL; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Poynter JN; Division of Pediatric Epidemiology and Clinical Research and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
  • Purdue MP; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Robien K; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC.
  • Rosenberg L; Slone Epidemiology Center at Boston University, Boston, Massachusetts.
  • Sahasrabuddhe VV; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Schairer C; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Sesso HD; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
  • Sigurdson AJ; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
  • Stevens VL; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
  • Wactawski-Wende J; Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York.
  • Zeleniuch-Jacquotte A; Department of Population Health, New York University School of Medicine, New York, New York.
  • Renehan AG; Faculty Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom.
  • McGlynn KA; Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Cancer Res ; 76(20): 6076-6083, 2016 10 15.
Article en En | MEDLINE | ID: mdl-27742674
Incidence rates for liver cancer have increased 3-fold since the mid-1970s in the United States in parallel with increasing trends for obesity and type II diabetes mellitus. We conducted an analysis of baseline body mass index (BMI), waist circumference (WC), and type II diabetes mellitus with risk of liver cancer. The Liver Cancer Pooling Project maintains harmonized data from 1.57 million adults enrolled in 14 U.S.-based prospective studies. Cox regression estimated HRs and 95% confidence intervals (CI) adjusted for age, sex, study center, alcohol, smoking, race, and BMI (for WC and type II diabetes mellitus). Stratified analyses assessed whether the BMI-liver cancer associations differed by hepatitis sera-positivity in nested analyses for a subset of cases (n = 220) and controls (n = 547). After enrollment, 2,162 incident liver cancer diagnoses were identified. BMI, per 5 kg/m2, was associated with higher risks of liver cancer, more so for men (HR = 1.38; 95% CI, 1.30-1.46) than women (HR = 1.25; 95% CI, 1.17-1.35; Pinteraction = 0.02). WC, per 5 cm, was associated with higher risks of liver cancer, approximately equally by sex (overall, HR = 1.08; 95% CI, 1.04-1.13). Type II diabetes mellitus was associated with higher risk of liver cancer (HR = 2.61; 95% CI, 2.34-2.91). In stratified analyses, there was a null association between BMI and liver cancer risk for participants who were sera-positive for hepatitis. This study suggests that high BMI, high WC, and type II diabetes mellitus are associated with higher risks of liver cancer and that the association may differ by status of viral hepatitis infection. Cancer Res; 76(20); 6076-83. ©2016 AACR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Masa Corporal / Diabetes Mellitus Tipo 2 / Circunferencia de la Cintura / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Año: 2016 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Índice de Masa Corporal / Diabetes Mellitus Tipo 2 / Circunferencia de la Cintura / Neoplasias Hepáticas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Res Año: 2016 Tipo del documento: Article País de afiliación: Georgia Pais de publicación: Estados Unidos