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Worldwide Esophageal Cancer Collaboration: clinical staging data.
Rice, T W; Apperson-Hansen, C; DiPaola, L M; Semple, M E; Lerut, T E M R; Orringer, M B; Chen, L-Q; Hofstetter, W L; Smithers, B M; Rusch, V W; Wijnhoven, B P L; Chen, K N; Davies, A R; D'Journo, X B; Kesler, K A; Luketich, J D; Ferguson, M K; Räsänen, J V; van Hillegersberg, R; Fang, W; Durand, L; Allum, W H; Cecconello, I; Cerfolio, R J; Pera, M; Griffin, S M; Burger, R; Liu, J-F; Allen, M S; Law, S; Watson, T J; Darling, G E; Scott, W J; Duranceau, A; Denlinger, C E; Schipper, P H; Ishwaran, H; Blackstone, E H.
Afiliación
  • Rice TW; Cleveland Clinic, Cleveland, Ohio, USA. ricet@ccf.org.
  • Apperson-Hansen C; Case Western Reserve University, Cleveland, Ohio, USA.
  • DiPaola LM; Cleveland Clinic, Cleveland, Ohio, USA.
  • Semple ME; Cleveland Clinic, Cleveland, Ohio, USA.
  • Lerut TE; University Ziekenhuizen Leuven, Leuven, Belgium.
  • Orringer MB; University of Michigan, Ann Arbor, Michigan, USA.
  • Chen LQ; West China Hospital of Sichuan University, Chengdu, Sichuan, China.
  • Hofstetter WL; University of Texas MD Anderson Hospital, Houston, Texas, USA.
  • Smithers BM; University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
  • Rusch VW; Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
  • Wijnhoven BP; Erasmus Medical Center, Rotterdam, The Netherlands.
  • Chen KN; Beijing Cancer Hospital, Beijing, China.
  • Davies AR; Guy's & St Thomas' Hospitals, London, UK.
  • D'Journo XB; Hôpital Nord, Marseille, France.
  • Kesler KA; Indiana University Medical Center, Indianapolis, Indiana, USA.
  • Luketich JD; University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
  • Ferguson MK; Department of Surgery, The University of Chicago, Chicago, Illinois, USA.
  • Räsänen JV; Helsinki University Hospital, Helsinki, Finland.
  • van Hillegersberg R; University Medical Center Utrecht, Utrecht, The Netherlands.
  • Fang W; Shanghai Chest Hospital, Shanghai, China.
  • Durand L; Hospital de Clinicas, University of Buenos Aires, Buenos Aires, Argentina.
  • Allum WH; Royal Marsden NHS Foundation Trust, London, UK.
  • Cecconello I; University of São Paulo, São Paulo, Brazil.
  • Cerfolio RJ; University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Pera M; Hospital Universitario del Mar, Barcelona, Spain.
  • Griffin SM; University of Newcastle upon Tyne, Newcastle, UK.
  • Burger R; Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
  • Liu JF; Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
  • Allen MS; Mayo Clinic, Rochester, Minnesota, USA.
  • Law S; University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong, China.
  • Watson TJ; University of Rochester, Rochester, New York, USA.
  • Darling GE; Toronto General Hospital, Toronto, Ontario, Canada.
  • Scott WJ; Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
  • Duranceau A; University of Montreal, Montreal, Quebec, Canada.
  • Denlinger CE; Medical University of South Carolina, Charleston, South Carolina, USA.
  • Schipper PH; Oregon Health and Science University, Portland, Oregon, USA.
  • Ishwaran H; University of Miami, Miami, Florida, USA.
  • Blackstone EH; Cleveland Clinic, Cleveland, Ohio, USA.
Dis Esophagus ; 29(7): 707-714, 2016 Oct.
Article en En | MEDLINE | ID: mdl-27731549
To address uncertainty of whether clinical stage groupings (cTNM) for esophageal cancer share prognostic implications with pathologic groupings after esophagectomy alone (pTNM), we report data-simple descriptions of patient characteristics, cancer categories, and non-risk-adjusted survival-for clinically staged patients from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions from six continents submitted data using variables with standard definitions: demographics, comorbidities, clinical cancer categories, and all-cause mortality from first management decision. Of 22,123 clinically staged patients, 8,156 had squamous cell carcinoma, 13,814 adenocarcinoma, 116 adenosquamous carcinoma, and 37 undifferentiated carcinoma. Patients were older (62 years) men (80%) with normal body mass index (18.5-25 mg/kg2 , 47%), little weight loss (2.4 ± 7.8 kg), 0-1 ECOG performance status (67%), and history of smoking (67%). Cancers were cT1 (12%), cT2 (22%), cT3 (56%), cN0 (44%), cM0 (95%), and cG2-G3 (89%); most involved the distal esophagus (73%). Non-risk-adjusted survival for squamous cell carcinoma was not distinctive for early cT or cN; for adenocarcinoma, it was distinctive for early versus advanced cT and for cN0 versus cN+. Patients with early cancers had worse survival and those with advanced cancers better survival than expected from equivalent pathologic categories based on prior WECC pathologic data. Thus, clinical and pathologic categories do not share prognostic implications. This makes clinically based treatment decisions difficult and pre-treatment prognostication inaccurate. These data will be the basis for the 8th edition cancer staging manuals following risk adjustment for patient characteristics, cancer categories, and treatment characteristics and should direct 9th edition data collection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma / Estadificación de Neoplasias Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Esophagus Asunto de la revista: GASTROENTEROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Esofágicas / Carcinoma / Estadificación de Neoplasias Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Esophagus Asunto de la revista: GASTROENTEROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos