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Molecular signatures associated with cognitive deficits in schizophrenia: a study of biopsied olfactory neural epithelium.
Horiuchi, Y; Kondo, M A; Okada, K; Takayanagi, Y; Tanaka, T; Ho, T; Varvaris, M; Tajinda, K; Hiyama, H; Ni, K; Colantuoni, C; Schretlen, D; Cascella, N G; Pevsner, J; Ishizuka, K; Sawa, A.
Afiliación
  • Horiuchi Y; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Kondo MA; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Okada K; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Takayanagi Y; Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA.
  • Tanaka T; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Ho T; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Varvaris M; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Tajinda K; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Hiyama H; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Ni K; Pharmacology Research Labs, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan.
  • Colantuoni C; Lieber Institute for Brain Development, Baltimore, MD, USA.
  • Schretlen D; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Cascella NG; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Pevsner J; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
  • Ishizuka K; Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA.
  • Sawa A; Department of Psychiatry, Johns Hopkins University, Baltimore, MD, USA.
Transl Psychiatry ; 6(10): e915, 2016 10 11.
Article en En | MEDLINE | ID: mdl-27727244
Cognitive impairment is a key feature of schizophrenia (SZ) and determines functional outcome. Nonetheless, molecular signatures in neuronal tissues that associate with deficits are not well understood. We conducted nasal biopsy to obtain olfactory epithelium from patients with SZ and control subjects. The neural layers from the biopsied epithelium were enriched by laser-captured microdissection. We then performed an unbiased microarray expression study and implemented a systematic neuropsychological assessment on the same participants. The differentially regulated genes in SZ were further filtered based on correlation with neuropsychological traits. This strategy identified the SMAD 5 gene, and real-time quantitative PCR analysis also supports downregulation of the SMAD pathway in SZ. The SMAD pathway has been important in multiple tissues, including the role for neurodevelopment and bone formation. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD pathway may be a novel target in addressing cognitive deficit of SZ in future studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Mucosa Olfatoria / Proteína Smad5 / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Transl Psychiatry Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Mucosa Olfatoria / Proteína Smad5 / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Transl Psychiatry Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos