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NAT2 slow acetylator associated with anti-tuberculosis drug-induced liver injury in Thai patients.
Wattanapokayakit, S; Mushiroda, T; Yanai, H; Wichukchinda, N; Chuchottawon, C; Nedsuwan, S; Rojanawiwat, A; Denjanta, S; Kantima, T; Wongyai, J; Suwankesawong, W; Rungapiromnan, W; Kidkeukarun, R; Bamrungram, W; Chaiwong, A; Suvichapanich, S; Mahasirimongkol, S; Tokunaga, K.
Afiliación
  • Wattanapokayakit S; Medical Genetics Center, Medical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
  • Mushiroda T; Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Yanai H; Fukujuji Hospital, Japan Anti-tuberculosis Association, Kiyose, Japan.
  • Wichukchinda N; Medical Genetics Center, Medical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
  • Chuchottawon C; Central Chest Institute of Thailand, Department of Medical Services, Ministry of Public Health, Nonthaburi, Thailand.
  • Nedsuwan S; Chiangrai Prachanukroh Hospital, Department of Social and Preventive Medicine, Ministry of Public Health, Chiang Rai, Thailand.
  • Rojanawiwat A; Medical Genetics Center, Medical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
  • Denjanta S; Chiangrai Prachanukroh Hospital, Department of Social and Preventive Medicine, Ministry of Public Health, Chiang Rai, Thailand.
  • Kantima T; TB/HIV Research Foundation, Chiang Rai, Thailand.
  • Wongyai J; TB/HIV Research Foundation, Chiang Rai, Thailand.
  • Suwankesawong W; Health Product Vigilance Centre, Food and Drug Administration, Ministry of Public Health, Nonthaburi, Thailand.
  • Rungapiromnan W; Health Product Vigilance Centre, Food and Drug Administration, Ministry of Public Health, Nonthaburi, Thailand.
  • Kidkeukarun R; Buddhachinaraj Hospital, Phitsanulok, Thailand.
  • Bamrungram W; Rayong Hospital, Rayong, Thailand.
  • Chaiwong A; Maesot Hospital, Tak, Thailand.
  • Suvichapanich S; Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
  • Mahasirimongkol S; Medical Genetics Center, Medical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
  • Tokunaga K; Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Int J Tuberc Lung Dis ; 20(10): 1364-1369, 2016 10.
Article en En | MEDLINE | ID: mdl-27725049
BACKGROUND: Anti-tuberculosis drug-induced liver injury (AT-DILI) is one of the most common forms of drug-induced liver injury (DILI) in high tuberculosis (TB) burden countries. Among anti-tuberculosis drugs, isoniazid is the main cause of hepatotoxicity in patients with AT-DILI. OBJECTIVE: To investigate the association of AT-DILI with N-acetyltransferase 2 (NAT2) genotype status in Thai TB patients. METHODS: We enrolled 53 patients diagnosed with AT-DILI and 85 patients who tolerated anti-tuberculosis treatment as controls. Acetylator status was determined based on the inferred NAT2 haplotypes from four common single-nucleotide polymorphisms (SNPs) in Thais using Sanger sequencing. RESULTS: Phenotype frequencies of the NAT2 acetylator in AT-DILI patients were respectively 71.7%, 22.6% and 5.7% for slow, intermediate and rapid acetylators. Among slow, intermediate, and rapid acetylators in treatment tolerant controls, phenotype frequencies were respectively 22.4%, 62.4% and 15.3%. Slow NAT2 acetylators demonstrated a significant association with risk of AT-DILI. The odds ratio of comparing slow NAT2 acetylator in DILI patients and tolerance was 8.80 (95%CI 4.01-19.31, P = 1.53 × 10-8). CONCLUSIONS: Slow acetylator status in the NAT2 genotype is a significant risk factor for DILI in Thai patients with TB. This evidence provides confirmatory data in support of the role of NAT2 in AT-DILI in the Thai population.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arilamina N-Acetiltransferasa / Tuberculosis / Enfermedad Hepática Inducida por Sustancias y Drogas / Antituberculosos Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int J Tuberc Lung Dis Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Francia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arilamina N-Acetiltransferasa / Tuberculosis / Enfermedad Hepática Inducida por Sustancias y Drogas / Antituberculosos Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int J Tuberc Lung Dis Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Francia