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Mercury sulfides are much less nephrotoxic than mercury chloride and methylmercury in mice.
Liu, Jie; Lu, Yuan-Fu; Li, Wen-Kai; Zhou, Zheng-Ping; Li, Ying-Ying; Yang, Xi; Li, Cen; Du, Yu-Zhi; Wei, Li-Xin.
Afiliación
  • Liu J; Zunyi Medical College, Zunyi, China. Electronic address: Jieliu@zmc.edu.cn.
  • Lu YF; Zunyi Medical College, Zunyi, China.
  • Li WK; Zunyi Medical College, Zunyi, China.
  • Zhou ZP; Zunyi Medical College, Zunyi, China.
  • Li YY; Zunyi Medical College, Zunyi, China.
  • Yang X; Zunyi Medical College, Zunyi, China.
  • Li C; Northwest Plateau Institute of biology of Chinese Academy of Sciences, Xining, China.
  • Du YZ; Northwest Plateau Institute of biology of Chinese Academy of Sciences, Xining, China.
  • Wei LX; Northwest Plateau Institute of biology of Chinese Academy of Sciences, Xining, China.
Toxicol Lett ; 262: 153-160, 2016 Nov 16.
Article en En | MEDLINE | ID: mdl-27720909
Mercury sulfides (α-HgS, ß-HgS) are frequently included in traditional medicines. Mercury is known for nephrotoxicity, their safety is of concern. To address this question, mice were orally administrated with Zuotai (54% ß-HgS, 30mg/kg), α-HgS (HgS, 30mg/kg), HgCl2 (33.6mg/kg), or MeHgCl (3.1mg/kg) for 7days, and nephrotoxicity was examined. Animal body weights were decreased by HgCl2 and to a lesser extent by MeHg, but unaltered after Zuotai and HgS. HgCl2 and MeHg produced renal tubular vacuolation, interstitial inflammation and cell degeneration with protein cysts in the tubular lumen, while these pathological lesions were mild in Zuotai and HgS-treated mice. Electron microscopy showed that HgCl2 and MeHg produced spotted swelling endothelium reticulum, while these lesions were mild or absent in Zuotai and HgS-treated mice. Renal Hg contents reached 250-300ng/mg kidney in HgCl2 and MeHg groups as compared to 2-3ng/mg in Zuotai and HgS groups. The expression of kidney injury biomarkers, kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (Ngal), were increased after HgCl2 and MeHg, but unaltered after Zuotai and HgS. The expression of renal influx transporters Oat3 and Oatp4c1 was decreased, while the expression of renal efflux transporter such as Mrp2, Mrp4, and Mate2 was increased following HgCl2 and MeHg. These gene expressions were unchanged after Zuotai and HgS. In summary, both α-HgS and ß-HgS are less nephrotoxic than HgCl2 and MeHg, indicating that chemical forms of mercury are a major determinant of mercury disposition and toxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Mercurio / Enfermedades Renales / Cloruro de Mercurio / Compuestos de Metilmercurio Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Mercurio / Enfermedades Renales / Cloruro de Mercurio / Compuestos de Metilmercurio Límite: Animals Idioma: En Revista: Toxicol Lett Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos