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A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies.
Rudd, Stacey E; Roselt, Peter; Cullinane, Carleen; Hicks, Rodney J; Donnelly, Paul S.
Afiliación
  • Rudd SE; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria 3010, Australia. pauld@unimelb.edu.au.
  • Roselt P; Research Division, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne 3000, Victoria, Australia.
  • Cullinane C; Research Division, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne 3000, Victoria, Australia and The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia. Rod.Hicks@petermac.org.
  • Hicks RJ; The Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, Australia. Rod.Hicks@petermac.org and Centre for Cancer Imaging, Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne 3000, Victoria, Australia.
  • Donnelly PS; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Victoria 3010, Australia. pauld@unimelb.edu.au.
Chem Commun (Camb) ; 52(80): 11889-11892, 2016 Sep 29.
Article en En | MEDLINE | ID: mdl-27711378
A squaramide ester derivative of desferrioxamine B (H3DFO) that is compatible with aqueous solvents and does not induce antibody aggregation is used to attach the siderophore to the antibody trastuzumab. The new conjugates were radiolabeled with zirconium-89 to give complexes that are more resistant to ligand exchange when compared to currently used H3DFO derivatives and result in high quality positron emission tomography images in mouse models of HER2 positive breast cancer.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deferoxamina / Anticuerpos Monoclonales Humanizados / Trastuzumab Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Deferoxamina / Anticuerpos Monoclonales Humanizados / Trastuzumab Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido