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Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously.
Sugiyama, Shin-Ichiro; Endo, Hidenori; Niizuma, Kuniyasu; Endo, Toshiki; Funamoto, Kenichi; Ohta, Makoto; Tominaga, Teiji.
Afiliación
  • Sugiyama SI; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan; Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan; Department of Neuroanesthesia, Kohnan Hospital, Sendai, Japan.
  • Endo H; Department of Neurosurgery, Kohnan Hospital, Sendai, Japan.
  • Niizuma K; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Endo T; Department of Neurosurgery, Kohnan Hospital, Sendai, Japan.
  • Funamoto K; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
  • Ohta M; Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan; Institute of Fluid Science, Tohoku University, Sendai, Japan.
  • Tominaga T; Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Comput Math Methods Med ; 2016: 2386031, 2016.
Article en En | MEDLINE | ID: mdl-27703491
This was a proof-of-concept computational fluid dynamics (CFD) study designed to identify atherosclerotic changes in intracranial aneurysms. We selected 3 patients with multiple unruptured aneurysms including at least one with atherosclerotic changes and investigated whether an image-based CFD study could provide useful information for discriminating the atherosclerotic aneurysms. Patient-specific geometries were constructed from three-dimensional data obtained using rotational angiography. Transient simulations were conducted under patient-specific inlet flow rates measured by phase-contrast magnetic resonance velocimetry. In the postanalyses, we calculated time-averaged wall shear stress (WSS), oscillatory shear index, and relative residence time (RRT). The volume of blood flow entering aneurysms through the neck and the mean velocity of blood flow inside aneurysms were examined. We applied the age-of-fluid method to quantitatively assess the residence of blood inside aneurysms. Atherosclerotic changes coincided with regions exposed to disturbed blood flow, as indicated by low WSS and long RRT. Blood entered aneurysms in phase with inlet flow rates. The mean velocities of blood inside atherosclerotic aneurysms were lower than those inside nonatherosclerotic aneurysms. Blood in atherosclerotic aneurysms was older than that in nonatherosclerotic aneurysms, especially near the wall. This proof-of-concept study demonstrated that CFD analysis provided detailed information on the exchange and residence of blood that is useful for the diagnosis of atherosclerotic changes in intracranial aneurysms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma Intracraneal / Aterosclerosis / Hemodinámica Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Comput Math Methods Med Asunto de la revista: INFORMATICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma Intracraneal / Aterosclerosis / Hemodinámica Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Comput Math Methods Med Asunto de la revista: INFORMATICA MEDICA Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos