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Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system.
Sigal, Iliya; Koletar, Margaret M; Ringuette, Dene; Gad, Raanan; Jeffrey, Melanie; Carlen, Peter L; Stefanovic, Bojana; Levi, Ofer.
Afiliación
  • Sigal I; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; The Edward S. Rogers Sr. Department of Electrical and Computer Engineering, 10 King's College Road, Toronto, ON M5S 3G4, Canada.
  • Koletar MM; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
  • Ringuette D; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada.
  • Gad R; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; The Edward S. Rogers Sr. Department of Electrical and Computer Engineering, 10 King's College Road, Toronto, ON M5S 3G4, Canada.
  • Jeffrey M; Krembil Research Institute, 60 Leonard Avenue, Toronto, ON M5T 2S1, Canada.
  • Carlen PL; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Krembil Research Institute, 60 Leonard Avenue, Toronto, ON M5T 2S1, Canada.
  • Stefanovic B; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada; Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.
  • Levi O; Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; The Edward S. Rogers Sr. Department of Electrical and Computer Engineering, 10 King's College Road, Toronto, ON M5S 3G4, Canada.
Biomed Opt Express ; 7(9): 3596-3609, 2016 Sep 01.
Article en En | MEDLINE | ID: mdl-27699123
We report on a miniature label-free imaging system for monitoring brain blood flow and blood oxygenation changes in awake, freely behaving rats. The device, weighing 15 grams, enables imaging in a ∼ 2 × 2 mm field of view with 4.4 µm lateral resolution and 1 - 8 Hz temporal sampling rate. The imaging is performed through a chronically-implanted cranial window that remains optically clear between 2 to > 6 weeks after the craniotomy. This imaging method is well suited for longitudinal studies of chronic models of brain diseases and disorders. In this work, it is applied to monitoring neurovascular coupling during drug-induced absence-like seizures 6 weeks following the craniotomy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: Biomed Opt Express Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: Biomed Opt Express Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos