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Dried blood spot analysis of gabapentin as a valid alternative for serum: a bridging study.
Sadones, Nele; Van Bever, Elien; Van Bortel, Luc; Lambert, Willy E; Stove, Christophe P.
Afiliación
  • Sadones N; Laboratory of Toxicology, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
  • Van Bever E; Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.
  • Van Bortel L; Heymans Institute of Pharmacology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.
  • Lambert WE; Laboratory of Toxicology, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium.
  • Stove CP; Laboratory of Toxicology, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address: Christophe.Stove@UGent.be.
J Pharm Biomed Anal ; 132: 72-76, 2017 Jan 05.
Article en En | MEDLINE | ID: mdl-27697572
We evaluated the applicability of a validated GC-MS method for the determination of gabapentin in dried blood spots (DBS). Important for the acceptance of DBS sampling as an alternative sampling strategy is the possibility to base solid conclusions on the quantification. Therefore, bridging studies -studies in which the correlation between both DBS and a reference matrix (e.g. serum) is evaluated statistically- need to be conducted. To this end, a comparative study was set up to quantify gabapentin in both blood (DBS) and serum samples. Statistically significant differences between DBS and serum concentrations were found (p<0.001). A mean blood-to-serum ratio of 0.85 was observed, which is in line with expectations. Calculated serum concentrations (obtained by dividing the DBS concentrations by 0.85) demonstrated a good correlation with measured serum concentrations, with 87% of samples fulfilling the criterion for incurred sample reanalysis. Furthermore, our data indicate a good correlation between capillary and venous concentrations. Conclusively, this study demonstrated that DBS are a valid alternative to serum for the determination of gabapentin.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manejo de Especímenes / Monitoreo de Drogas / Ácidos Ciclohexanocarboxílicos / Pruebas con Sangre Seca / Ácido gamma-Aminobutírico / Aminas Tipo de estudio: Diagnostic_studies Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: J Pharm Biomed Anal Año: 2017 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manejo de Especímenes / Monitoreo de Drogas / Ácidos Ciclohexanocarboxílicos / Pruebas con Sangre Seca / Ácido gamma-Aminobutírico / Aminas Tipo de estudio: Diagnostic_studies Límite: Adolescent / Adult / Humans / Middle aged Idioma: En Revista: J Pharm Biomed Anal Año: 2017 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido