Novel Structural Hybrids on the Base of Benzofuroxans and Furoxans. Mini-Review.
Curr Top Med Chem
; 17(9): 986-1005, 2017.
Article
en En
| MEDLINE
| ID: mdl-27697059
Hybrid drug strategy is based on the combination of two or more pharmacophores into a new chemical entity to improve the properties of the original compounds or to obtain double action of resulting molecule. Hybrid molecules, comprised of some pharmacophore and nitric oxide (NO) donor moiety, constitute one of the more promising approaches for the design of drugs. Furoxans and benzofuroxans are considered NO releasing prodrugs and are of great interest for researchers. In this review we will focus on furoxan and benzofuroxan hybrids described in literature during the last years (from 2005 to 2016).
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxadiazoles
/
Benzoxazoles
/
Profármacos
/
Donantes de Óxido Nítrico
/
Óxido Nítrico
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Top Med Chem
Asunto de la revista:
QUIMICA
Año:
2017
Tipo del documento:
Article
Pais de publicación:
Emiratos Árabes Unidos