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Targeted delivery of rifampicin to tuberculosis-infected macrophages: design, in-vitro, and in-vivo performance of rifampicin-loaded poly(ester amide)s nanocarriers.
Amarnath Praphakar, Rajendran; Munusamy, Murugan A; Sadasivuni, Kishor Kumar; Rajan, Mariappan.
Afiliación
  • Amarnath Praphakar R; Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-21, Tamil Nadu, India. Electronic address: amarnathyuvi@gmail.com.
  • Munusamy MA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
  • Sadasivuni KK; Department of Mechanical & Industrial Engineering, College of Engineering, Qatar University, PO Box 2713, Doha, Qatar.
  • Rajan M; Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-21, Tamil Nadu, India. Electronic address: rajanm153@gmail.com.
Int J Pharm ; 513(1-2): 628-635, 2016 Nov 20.
Article en En | MEDLINE | ID: mdl-27693734
We have developed a nano drug delivery system for the treatment of tuberculosis (TB) using rifampicin (RF) encapsulated in poly(ester amide)s nanoparticles (PEA-RF-NPs), which are biocompatible polymers. In this study, biodegradable amino acid based poly(ester amide)s (PEAs) were synthesized by the poly condensation reaction and RF-loaded NPs were fabricated by the dialysis method. The surface morphology and in-vitro drug release efficiency were examined. The effect of time and temperature on the cellular uptake of PEA-RF-NPs in NR8383 cells was evaluated. Fluorescence microscopic results of PEA-RF-NPs from NR8383 cell lines suggest its potential application in treating TB. The antibacterial activity of RF against Mycobacterium smegmatis was also evaluated. Based on these results, this approach provides a new means for controlled and efficient release of RF using the PEA-NPs delivery system and is promising for the treatment of TB.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Rifampin / Portadores de Fármacos / Nanopartículas / Amidas / Antibióticos Antituberculosos Límite: Animals Idioma: En Revista: Int J Pharm Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Rifampin / Portadores de Fármacos / Nanopartículas / Amidas / Antibióticos Antituberculosos Límite: Animals Idioma: En Revista: Int J Pharm Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos