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Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol.
Hickman, Thu-Trang; Shuman, Matthew E; Johnson, Tatyana A; Yang, Felix; Rice, Rebecca R; Rice, Isaac M; Chung, Esther H; Wiemann, Robert; Tinl, Megan; Iracheta, Christine; Chen, Grace; Flynn, Patricia; Mondello, Mary Beth; Thompson, Jillian; Meadows, Mary-Ellen; Carroll, Rona S; Yang, Hong Wei; Xing, Hongyan; Pilgrim, David; Chiocca, E Antonio; Dunn, Ian F; Golby, Alexandra J; Johnson, Mark D.
Afiliación
  • Hickman TT; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Shuman ME; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Johnson TA; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Yang F; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Rice RR; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Rice IM; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Chung EH; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Wiemann R; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Tinl M; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Iracheta C; Department of Rehabilitation Services, Brigham and Women's Hospital; and.
  • Chen G; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Flynn P; Department of Rehabilitation Services, Brigham and Women's Hospital; and.
  • Mondello MB; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Thompson J; Department of Rehabilitation Services, Brigham and Women's Hospital; and.
  • Meadows ME; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Carroll RS; Department of Rehabilitation Services, Brigham and Women's Hospital; and.
  • Yang HW; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Xing H; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Pilgrim D; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Chiocca EA; Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Dunn IF; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Golby AJ; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
  • Johnson MD; Adult Hydrocephalus Program, Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School.
J Neurosurg ; 127(2): 240-248, 2017 Aug.
Article en En | MEDLINE | ID: mdl-27689463
OBJECTIVE Idiopathic normal pressure hydrocephalus (iNPH) is characterized by ventriculomegaly, gait difficulty, incontinence, and dementia. The symptoms can be ameliorated by CSF drainage. The object of this study was to identify factors associated with shunt-responsive iNPH. METHODS The authors reviewed the medical records of 529 patients who underwent shunt placement for iNPH at their institution between July 2001 and March 2015. Variables associated with shunt-responsive iNPH were identified using bivariate and multivariate analyses. Detailed alcohol consumption information was obtained for 328 patients and was used to examine the relationship between alcohol and shunt-responsive iNPH. A computerized patient registry from 2 academic medical centers was queried to determine the prevalence of alcohol abuse among 1665 iNPH patients. RESULTS Bivariate analysis identified associations between shunt-responsive iNPH and gait difficulty (OR 4.59, 95% CI 2.32-9.09; p < 0.0001), dementia (OR 1.79, 95% CI 1.14-2.80; p = 0.01), incontinence (OR 1.77, 95% CI 1.13-2.76; p = 0.01), and alcohol use (OR 1.98, 95% CI 1.23-3.16; p = 0.03). Borderline significance was observed for hyperlipidemia (OR 1.56, 95% CI 0.99-2.45; p = 0.054), a family history of hyperlipidemia (OR 3.09, 95% CI 0.93-10.26, p = 0.054), and diabetes (OR 1.83, 95% CI 0.96-3.51; p = 0.064). Multivariate analysis identified associations with gait difficulty (OR 3.98, 95% CI 1.81-8.77; p = 0.0006) and alcohol (OR 1.94, 95% CI 1.10-3.39; p = 0.04). Increased alcohol intake correlated with greater improvement after CSF drainage. Alcohol abuse was 2.5 times more prevalent among iNPH patients than matched controls. CONCLUSIONS Alcohol consumption is associated with the development of shunt-responsive iNPH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Derivación Ventriculoperitoneal / Alcoholismo / Hidrocéfalo Normotenso Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Neurosurg Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Derivación Ventriculoperitoneal / Alcoholismo / Hidrocéfalo Normotenso Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Neurosurg Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos