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How to facilitate early diagnosis of CNS involvement in malignant lymphoma.
Korfel, Agnieszka; Nowosielski, Martha; Pardo-Moreno, Javier; Penalver, Francisco Javier; Buda, Gabriele; Bennani, Hind; Costopoulos, Myrto; Le Garff-Tavernier, Magali; Soussain, Carole; Schmid, Mathias; Orfao, Jose Alberto; Glantz, Michael.
Afiliación
  • Korfel A; a Department of Hematology, Oncology and Tumor Immunology , Charite University Medicine Berlin , Berlin , Germany.
  • Nowosielski M; b Department of Neurology , Medical University Innsbruck , Innsbruck , Austria.
  • Pardo-Moreno J; c Department of Neurology , University Hospital King Juan Carlos , Madrid , Spain.
  • Penalver FJ; d Department of Hematology , University Hospital Foundation Alcorcón, Madrid , Spain.
  • Buda G; e Department of Hematology and Oncology , University of Pisa , Pisa , Italy.
  • Bennani H; f Department of Biology , Hôpital Foch , Suresnes , France.
  • Costopoulos M; g Department of Biological Hematology , Pitie Salpetriere Hospital , Paris , France.
  • Le Garff-Tavernier M; g Department of Biological Hematology , Pitie Salpetriere Hospital , Paris , France.
  • Soussain C; h Department of Hematology , Institut Curie - Hôpital René Huguenin , Paris , France.
  • Schmid M; i Department of Hematology and Oncology , Stadtspital Triemli Zürich , Zürich , Switzerland.
  • Orfao JA; j Department of Medicine and Cytometry Service , University of Salamanca , Salamanca , Spain.
  • Glantz M; k Penn State College of Medicine , Hershey , PA , USA.
Expert Rev Hematol ; 9(11): 1081-1091, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27677656
INTRODUCTION: Making the diagnosis of secondary CNS involvement in lymphoma can be difficult due to unspecific signs and symptoms, limited accessibility of brain/myelon parenchyma and low sensitivity and/or specifity of imaging and cerebrospinal fluid (CSF) examination currently available. Areas covered: MRI of the total neuroaxis followed by CSF cytomorphology and flow cytometry are methods of choice when CNS lymphoma (CNSL) is suspected. To reduce the numerous pitfalls of these examinations several aspects should be considered. New CSF biomarkers might be of potential diagnostic value. Attempts to standardize response criteria are presented. Expert commentary: Diagnosing CNSL remains challenging. Until diagnostic methods combining high sensitivity with high specifity are routinely introduced, high level of awareness and optimal utilization of examinations currently available are needed to early diagnose this potentially devastating disease.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Sistema Nervioso Central / Linfoma Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Expert Rev Hematol Asunto de la revista: HEMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Buscar en Google
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Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Sistema Nervioso Central / Linfoma Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Humans Idioma: En Revista: Expert Rev Hematol Asunto de la revista: HEMATOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido