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Low-grade Schwann cell neoplasms with leptomeningeal dissemination: clinicopathologic and autopsy findings.
Rodriguez, Erika F; Blakeley, Jaishri; Langmead, Shannon; Olivi, Alessandro; Tufaro, Anthony; Tabbarah, Abeer; Berkenblit, Gail; Sacks, Justin M; Newsome, Scott D; Montgomery, Elizabeth; Rodriguez, Fausto J.
Afiliación
  • Rodriguez EF; Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Blakeley J; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21231; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Langmead S; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Olivi A; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Tufaro A; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Tabbarah A; Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Berkenblit G; Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Sacks JM; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Newsome SD; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Montgomery E; Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231.
  • Rodriguez FJ; Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231. Electronic address: frodrig4@jhmi.edu.
Hum Pathol ; 60: 121-128, 2017 02.
Article en En | MEDLINE | ID: mdl-27666764
Leptomeningeal dissemination of low-grade Schwann cell neoplasms is an exceptionally rare occurrence and has not been well documented in the literature. We encountered 2 cases of leptomeningeal dissemination of low-grade Schwann cell neoplasms. Patient 1 was a 63-year-old woman with neurofibromatosis type 1 and a progressive low-grade malignant peripheral nerve sheath tumor developing from a diffuse/plexiform orbital neurofibroma that arose in childhood. The neoplasm demonstrated local and leptomeningeal dissemination intracranially leading to the patient's death. There was partial loss of H3K27 tri-methylation, p16 and collagen IV. Patient 2 was a 60-year-old man without neurofibromatosis type 1 who presented with cranial nerve symptoms and a disseminated neoplasm with a Schwann cell phenotype. The neoplasm stabilized after irradiation and chemotherapy, but the patient died of medical complications. Autopsy findings documented disseminated leptomeningeal disease in the intracranial and spinal compartment. H3K27M tri-methylation was preserved. The clinicopathologic and autopsy findings are studied and presented, and the literature is reviewed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de Schwann / Neurofibromatosis 1 / Neoplasias Meníngeas / Neurilemoma Tipo de estudio: Diagnostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células de Schwann / Neurofibromatosis 1 / Neoplasias Meníngeas / Neurilemoma Tipo de estudio: Diagnostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2017 Tipo del documento: Article Pais de publicación: Estados Unidos