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A global multicenter study on reference values: 2. Exploration of sources of variation across the countries.
Ichihara, Kiyoshi; Ozarda, Yesim; Barth, Julian H; Klee, George; Shimizu, Yoshihisa; Xia, Liangyu; Hoffmann, Mariza; Shah, Swarup; Matsha, Tandi; Wassung, Janette; Smit, Francois; Ruzhanskaya, Anna; Straseski, Joely; Bustos, Daniel N; Kimura, Shogo; Takahashi, Aki.
Afiliación
  • Ichihara K; Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Ube, Japan. Electronic address: ichihara@yamaguchi-u.ac.jp.
  • Ozarda Y; Department of Medical Biochemistry, Uludag University School of Medicine, Bursa, Turkey.
  • Barth JH; Blood Sciences, Leeds General Infirmary, Leeds, UK.
  • Klee G; Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.
  • Shimizu Y; Department of Medical Life Science, Faculty of Medical Bioscience, Kyushu University of Health and Welfare, Nobeoka, Japan.
  • Xia L; Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China.
  • Hoffmann M; Division of Chemical Pathology, University of Stellenbosch, National Health Laboratory Services, Tygerberg, South Africa.
  • Shah S; Department of Laboratory Medicine, P. D. Hinduja National Hospital and Medical Research Center, Mumbai, India.
  • Matsha T; Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa.
  • Wassung J; PathCare Laboratories, Cape Town, South Africa.
  • Smit F; Department of Biomedical Sciences, Faculty of Health and Wellness Science, Cape Peninsula University of Technology, Cape Town, South Africa; PathCare Laboratories, Cape Town, South Africa.
  • Ruzhanskaya A; Beckman Coulter LLC, Moscow, Russia.
  • Straseski J; ARUP Laboratories, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Bustos DN; Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
  • Kimura S; Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Ube, Japan.
  • Takahashi A; Beckman Coulter Japan, Tokyo, Japan.
Clin Chim Acta ; 467: 83-97, 2017 Apr.
Article en En | MEDLINE | ID: mdl-27666762
OBJECTIVES: The intent of this study, based on a global multicenter study of reference values (RVs) for serum analytes was to explore biological sources of variation (SVs) of the RVs among 12 countries around the world. METHODS: As described in the first part of this paper, RVs of 50 major serum analytes from 13,396 healthy individuals living in 12 countries were obtained. Analyzed in this study were 23 clinical chemistry analytes and 8 analytes measured by immunoturbidimetry. Multiple regression analysis was performed for each gender, country by country, analyte by analyte, by setting four major SVs (age, BMI, and levels of drinking and smoking) as a fixed set of explanatory variables. For analytes with skewed distributions, log-transformation was applied. The association of each source of variation with RVs was expressed as the partial correlation coefficient (rp). RESULTS: Obvious gender and age-related changes in the RVs were observed in many analytes, almost consistently between countries. Compilation of age-related variations of RVs after adjusting for between-country differences revealed peculiar patterns specific to each analyte. Judged fromthe rp, BMI related changes were observed for many nutritional and inflammatory markers in almost all countries. However, the slope of linear regression of BMI vs. RV differed greatly among countries for some analytes. Alcohol and smoking-related changes were observed less conspicuously in a limited number of analytes. CONCLUSION: The features of sex, age, alcohol, and smoking-related changes in RVs of the analytes were largely comparable worldwide. The finding of differences in BMI-related changes among countries in some analytes is quite relevant to understanding ethnic differences in susceptibility to nutritionally related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas de Laboratorio Clínico / Internacionalidad Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Female / Humans / Male Idioma: En Revista: Clin Chim Acta Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas de Laboratorio Clínico / Internacionalidad Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Female / Humans / Male Idioma: En Revista: Clin Chim Acta Año: 2017 Tipo del documento: Article Pais de publicación: Países Bajos