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Immunosuppressive effect of ASP2408, a novel CD86-selective variant of CTLA4-Ig, in rats and cynomolgus monkeys.
Oshima, Shinsuke; Fujii, Yasutomo; Karrer, Erik E; Takamura, Fujiko; Chapin, Steven J; Neighbors, Margaret; Viswanathan, Sridhar; Devens, Bruce H; Higashi, Yasuyuki; Mizuhara, Hidekazu.
Afiliación
  • Oshima S; Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 3058585, Japan. Electronic address: shinsuke.ooshima@astellas.com.
  • Fujii Y; Applied Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 3058585, Japan.
  • Karrer EE; Department of Molecular Biology, Perseid Therapeutics, Redwood City, CA 94063, USA.
  • Takamura F; Pharmacokinetics-Pharmacodynamics Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 3058585, Japan.
  • Chapin SJ; Department of Biology and Pharmacology, Perseid Therapeutics, Redwood City, CA 94063, USA.
  • Neighbors M; Department of Biology and Pharmacology, Perseid Therapeutics, Redwood City, CA 94063, USA.
  • Viswanathan S; Department of Process Development and Manufacturing, Perseid Therapeutics, Redwood City, CA 94063, USA.
  • Devens BH; Department of Biology and Pharmacology, Perseid Therapeutics, Redwood City, CA 94063, USA.
  • Higashi Y; Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 3058585, Japan.
  • Mizuhara H; Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tsukuba, Ibaraki 3058585, Japan.
Int Immunopharmacol ; 40: 310-317, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27662596
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígeno B7-2 / Inmunosupresores Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígeno B7-2 / Inmunosupresores Límite: Animals Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2016 Tipo del documento: Article Pais de publicación: Países Bajos