An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion.

McCommis, Kyle S; Hodges, Wesley T; Bricker, Daniel K; Wisidagama, Dona R; Compan, Vincent; Remedi, Maria S; Thummel, Carl S; Finck, Brian N

McCommis, Kyle S; Hodges, Wesley T; Bricker, Daniel K; Wisidagama, Dona R; Compan, Vincent; Remedi, Maria S; Thummel, Carl S; Finck, Brian N.

Afiliación

McCommis KS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hodges WT; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Bricker DK; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Wisidagama DR; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Compan V; Institute of Functional Genomics, Labex ICST; INSERM U1191, CNRS UMR5203; University of Montpellier, Montpellier, France.
Remedi MS; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Thummel CS; Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: carl.thummel@genetics.utah.edu.
Finck BN; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: bfinck@dom.wustl.edu.

Mol Metab ; 5(8): 602-614, 2016 Aug.

Article en En | MEDLINE | ID: mdl-27656398

Palabras clave

DILP2, Drosophila insulin-like peptide 2; Diabetes; Drosophila; GSIS, glucose-stimulated insulin secretion; GTT, glucose tolerance test; IMM, inner mitochondrial membrane; IPCs, Insulin-producing Cells; ITT, insulin tolerance test; Insulin; MPC1 and MPC2, Mitochondrial Pyruvate Carrier 1 and 2; Mitochondria; OCR, oxygen consumption rates; Pdx1, pancreatic and duodenal homeobox 1; Pyruvate; RESPYR, REporter Sensitive to PYRuvate; Stimulus-coupled secretion; ß-Cell

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Metab Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania

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