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Hepatic fat and abdominal adiposity in early pregnancy together predict impaired glucose homeostasis in mid-pregnancy.
De Souza, L R; Berger, H; Retnakaran, R; Vlachou, P A; Maguire, J L; Nathens, A B; Connelly, P W; Ray, J G.
Afiliación
  • De Souza LR; Department of Obstetrics and Gynecology, St Michael's Hospital, Toronto, ON, Canada.
  • Berger H; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
  • Retnakaran R; Department of Obstetrics and Gynecology, St Michael's Hospital, Toronto, ON, Canada.
  • Vlachou PA; Keenan Research Centre for Biomedical Science of St Michael's Hospital, Toronto, Canada.
  • Maguire JL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Nathens AB; Department of Medical Imaging, St Michael's Hospital, Toronto, ON, Canada.
  • Connelly PW; Keenan Research Centre for Biomedical Science of St Michael's Hospital, Toronto, Canada.
  • Ray JG; Department of Surgery, Sunnybrook Health Sciences Center, Toronto, ON, Canada.
Nutr Diabetes ; 6(9): e229, 2016 09 19.
Article en En | MEDLINE | ID: mdl-27643724
Hepatic fat and abdominal adiposity individually reflect insulin resistance, but their combined effect on glucose homeostasis in mid-pregnancy is unknown. A cohort of 476 pregnant women prospectively underwent sonographic assessment of hepatic fat and visceral (VAT) and total (TAT) adipose tissue at 11-14 weeks' gestation. Logistic regression was used to assess the relation between the presence of maternal hepatic fat and/or the upper quartile (Q) of either VAT or TAT and the odds of developing the composite outcome of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or gestational diabetes mellitus at 24-28 weeks' gestation, based on a 75 g OGTT. Upon adjusting for maternal age, ethnicity, family history of DM and body mass index (BMI), the co-presence of hepatic fat and quartile 4 (Q4) of VAT (adjusted odds ratio (aOR) 6.5, 95% CI: 2.3-18.5) or hepatic fat and Q4 of TAT (aOR 7.8 95% CI 2.8-21.7) were each associated with the composite outcome, relative to women with neither sonographic feature. First-trimester sonographic evidence of maternal hepatic fat and abdominal adiposity may independently predict the development of impaired glucose homeostasis and GDM in mid-pregnancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Edad Gestacional / Intolerancia a la Glucosa / Obesidad Abdominal / Hígado Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Nutr Diabetes Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Edad Gestacional / Intolerancia a la Glucosa / Obesidad Abdominal / Hígado Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Nutr Diabetes Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido