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Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report.
Chêne, Arnaud; Houard, Sophie; Nielsen, Morten A; Hundt, Sophia; D'Alessio, Flavia; Sirima, Sodiomon B; Luty, Adrian J F; Duffy, Patrick; Leroy, Odile; Gamain, Benoit; Viebig, Nicola K.
Afiliación
  • Chêne A; Unité Biologie Intégrée du Globule Rouge, Laboratoire d'Excellence GR-Ex, Université Sorbonne Paris Cité, Université Paris Diderot, Inserm, Institut National de la Transfusion Sanguine, Paris, France.
  • Houard S; European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Voßstraße 2, 69115, Heidelberg, Germany.
  • Nielsen MA; Centre for Medical Parasitology at Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Hundt S; Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
  • D'Alessio F; European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Voßstraße 2, 69115, Heidelberg, Germany.
  • Sirima SB; European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Voßstraße 2, 69115, Heidelberg, Germany.
  • Luty AJ; Centre National de Recherche et de Formation sur le Paludisme, 01 BP 2208, Ouagadougou 01, Burkina Faso.
  • Duffy P; IRD MERIT UMR 216, 75006, Paris, France.
  • Leroy O; COMUE Sorbonne Paris Cité, Université Paris Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, 75270, Paris, France.
  • Gamain B; Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, MD, USA.
  • Viebig NK; European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Voßstraße 2, 69115, Heidelberg, Germany.
Malar J ; 15: 476, 2016 09 17.
Article en En | MEDLINE | ID: mdl-27639691
Placental malaria caused by Plasmodium falciparum infection constitutes a major health problem manifesting as severe disease and anaemia in the mother, impaired fetal development, low birth weight or spontaneous abortion. Prevention of placental malaria currently relies on two key strategies that are losing efficacy due to spread of resistance: long-lasting insecticide-treated nets and intermittent preventive treatment during pregnancy. A placental malaria vaccine would be an attractive, cost-effective complement to the existing control tools. Two placental malaria vaccine candidates are currently in Phase Ia/b clinical trials. During two workshops hosted by the European Vaccine Initiative, one in Paris in April 2014 and the other in Brussels in November 2014, the main actors in placental malaria vaccine research discussed the harmonization of clinical development plans and of the immunoassays with a goal to define standards that will allow comparative assessment of different placental malaria vaccine candidates. The recommendations of these workshops should guide researchers and clinicians in the further development of placental malaria vaccines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Placentarias / Inmunoensayo / Malaria Falciparum / Vacunas contra la Malaria Tipo de estudio: Guideline Límite: Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Malar J Asunto de la revista: MEDICINA TROPICAL Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Placentarias / Inmunoensayo / Malaria Falciparum / Vacunas contra la Malaria Tipo de estudio: Guideline Límite: Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: Malar J Asunto de la revista: MEDICINA TROPICAL Año: 2016 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido