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Study of apoptosis-related interactions in colorectal cancer.
Arora, Himanshu; Qureshi, Rehana; Rizvi, M A; Shrivastava, Sharad; Parihar, Mordhwaj S.
Afiliación
  • Arora H; School of Studies in Zoology and Biotechnology, Vikram University, Ujjain, MP, India. himanshu.harora@gmail.com.
  • Qureshi R; Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
  • Rizvi MA; Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, India.
  • Shrivastava S; School of Studies in Zoology and Biotechnology, Vikram University, Ujjain, MP, India.
  • Parihar MS; School of Studies in Zoology and Biotechnology, Vikram University, Ujjain, MP, India.
Tumour Biol ; 37(11): 14415-14425, 2016 Nov.
Article en En | MEDLINE | ID: mdl-27629291
Abnormalities in apoptotic functions contribute to the pathogenesis of colorectal cancer. In this study, molecular interactions behind the apoptotic regulation have been explored. For this purpose, enrichment analysis was performed considering microRNAs (miRNAs) that putatively target TP53 and altered during colon cancer. This revealed gene associated with both TP53 and miRNAs. Further analysis showed that a significant molecular interaction between the shortlisted candidates (TP53, miR-143, KRAS, BCL2, and PLK1) exists. Mutation study was conducted to confirm the clinical relevance of candidates. It showed that the mutation extent does not significantly alter survival in patients thus making these candidates suitable as drug targets. Overall, we showed the importance of interactions between TP53, miR-143, KRAS, BCL2, and PLK1 with respect to colorectal cancer using bioinformatics approach.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas p21(ras) / Proteínas Proto-Oncogénicas / Proteínas Serina-Treonina Quinasas / Apoptosis / Proteínas de Ciclo Celular / Proteínas Proto-Oncogénicas c-bcl-2 / MicroARNs Límite: Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteína p53 Supresora de Tumor / Proteínas Proto-Oncogénicas p21(ras) / Proteínas Proto-Oncogénicas / Proteínas Serina-Treonina Quinasas / Apoptosis / Proteínas de Ciclo Celular / Proteínas Proto-Oncogénicas c-bcl-2 / MicroARNs Límite: Humans Idioma: En Revista: Tumour Biol Asunto de la revista: NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos