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Dose, Plasma Level, and Treatment Outcome Among Methadone Patients in Shanghai, China.
Jiang, Haifeng; Hillhouse, Maureen; Du, Jiang; Pan, Shujun; Alfonso, Ang; Wang, Jun; Zhou, Zhirong; Yuan, Weijun; Ling, Walter; Zhao, Min.
Afiliación
  • Jiang H; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
  • Hillhouse M; Department of Psychiatry, Integrated Substance Abuse Program, University of California at Los Angeles, Los Angeles, CA, 90025, USA.
  • Du J; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
  • Pan S; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
  • Alfonso A; Department of Psychiatry, Integrated Substance Abuse Program, University of California at Los Angeles, Los Angeles, CA, 90025, USA.
  • Wang J; Shanghai Yangpu District Mental Health Center, Shanghai, 200093, China.
  • Zhou Z; Shanghai Xuhui District Mental Health Center, Shanghai, 200232, China.
  • Yuan W; Shanghai Hongkou District Mental Health Center, Shanghai, 200083, China.
  • Ling W; Department of Psychiatry, Integrated Substance Abuse Program, University of California at Los Angeles, Los Angeles, CA, 90025, USA.
  • Zhao M; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. drminzhao@gmail.com.
Neurosci Bull ; 32(6): 538-544, 2016 Dec.
Article en En | MEDLINE | ID: mdl-27612968
The purpose of this study was to investigate the blood levels of methadone in participants receiving methadone for the treatment of opioid dependence. After stabilization on methadone for four weeks, blood samples from 95 participants were collected between treatment weeks 4 and 12, before and after receiving doses of methadone, and its blood levels were measured. A multiple linear regression model was used to examine the association between methadone blood levels and the outcomes of methadone maintenance treatment (MMT). Outcome differences between participants who had high (≥2) or low (<2) peak-to-trough ratios were also compared using an independent sample t-test. The blood level of methadone was not correlated with the clinical outcome of MMT with the moderate range of doses given. However, the retention of patients who had a free peak-to-trough ratio >2 was significantly poorer than those whose ratio was <2. Thus, monitoring plasma methadone levels is unlikely to be effective for guiding dosing decisions in situations where compliance with MMT is already very high or when the methadone dose is no longer the dominant factor in determining the clinical outcome. However, monitoring plasma methadone levels is still helpful for guiding the dosage for patients with a rapid metabolism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resultado del Tratamiento / Tratamiento de Sustitución de Opiáceos / Metadona / Trastornos Relacionados con Opioides Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Neurosci Bull Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resultado del Tratamiento / Tratamiento de Sustitución de Opiáceos / Metadona / Trastornos Relacionados con Opioides Tipo de estudio: Prognostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Neurosci Bull Asunto de la revista: NEUROLOGIA Año: 2016 Tipo del documento: Article País de afiliación: China Pais de publicación: Singapur