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The Fimbrial Protein is a Virulence Factor and Potential Vaccine Antigen of Avibacterium paragallinarum.
Liu, C-C; Ou, S-C; Tan, D-H; Hsieh, M-K; Shien, J-H; Chang, P-C.
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  • Liu CC; A Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 40227, Taiwan.
  • Ou SC; A Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 40227, Taiwan.
  • Tan DH; A Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 40227, Taiwan.
  • Hsieh MK; A Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 40227, Taiwan.
  • Shien JH; B Department of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
  • Chang PC; A Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung 40227, Taiwan.
Avian Dis ; 60(3): 649-55, 2016 09.
Article en En | MEDLINE | ID: mdl-27610725
Fimbriae are recognized as virulence factors and potential vaccine antigens of several pathogenic bacteria, but the function of the fimbriae from Avibacterium paragallinarum is not well known. In this study, a gene encoding the fimbrial protein FlfA was identified in A. paragallinarum . Sequencing analysis of the putative promoter region of flfA suggests that flfA expression in A. paragallinarum might be controlled by phase variation. The flfA gene from A. paragallinarum was expressed as a recombinant protein (r-FlfA) in Escherichia coli . Immunization with r-FlfA conferred chickens protection against challenge infection with A. paragallinarum . Virulence assays showed that the flfA-deficient mutants of A. paragallinarum were less virulent than their parental wild-type strains. These results indicated that the fimbrial protein FlfA is a virulence factor and potential vaccine antigen from A. paragallinarum .
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Vacunas contra Haemophilus / Factores de Virulencia / Haemophilus paragallinarum / Inmunogenicidad Vacunal / Infecciones por Haemophilus Tipo de estudio: Prognostic_studies Idioma: En Revista: Avian Dis Año: 2016 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Vacunas contra Haemophilus / Factores de Virulencia / Haemophilus paragallinarum / Inmunogenicidad Vacunal / Infecciones por Haemophilus Tipo de estudio: Prognostic_studies Idioma: En Revista: Avian Dis Año: 2016 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos